nutrition lecture notes 2

nutrition lecture notes 2 - 12 Tuesday, May 11, 2010 10:56...

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Water Soluble vitamins Niacin 1) B6 2) Folate 3) B12 4) Vitamin C 5) Gets converted into the active form as NAD+/NADH or NADP+/NADPH a. Pyridine ring. b. It is a dinucleotide with two phosphates instead of one connecting to them i. Nicotinic acid-- know this structure and know the reaction shown 1) 2) Traps electrons and can store it to use other things. i) Nadh: redox rxns, catabolic, glycolysis and tca (used in catabolic reactions) a) (fatty acid biosynthesis) i) Nadph: involved in biosynthetic reactions and donates/reduces electrons b) There are two diff forms 3) H:- a) Oxidized is positively charged, reduced is neutral: 11:14 i) TRANSFERING ELECTRoNS WITH A PROTON b) 2e+ + H+ 4) The part that he expects you to know is what goes on at the active center ii. Don’t have to memorize structure, but there are some aspects you should recognize c. 1/2 niacin from food: whole grains, fruits i. You can make niacin out of an amino acid, tryptophan a) Tryptophan --->--> niacin 1) 1/2 comes from amino acid tryptophan ii. Heat stable, not destroyed by cooking iii. Deficiency: 1) RDA: 14-19 mg/day (doesn't expect you to memorize this number) iv. Sources of Niacin d. Vitamin B3: Niacin (Nicotinamide) dietary form I. 12 Tuesday, May 11, 2010 10:56 AM BIBC 120 Page 1
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pellagra (broken skin) a) Dementia b) Diarrhea c) Dermatitis d) Death e) When bound, body cannot get access to it 1) Corn: protein that binds niacin v. Can be prevented with other sources of protein. Primary foods eaten: corn, pork, black eyed peas-> corn kept niacin bound-> pellegra broke out + delirium + Dementia->death US epidemic: early 1900 in south Mega doses: 1.5-2 gm/day i. Army hazing story: gave them 3500 mg a) Flushing: burning sensation "every cell feels like it is on fire" 1) Swollen tongue 2) GI problems 3) Liver damage 4) Know this: UL: 35 mg/day ii. 11:26 iii. Niacin raise hdl-> decrease CVD e. Pyridine derivative i. When active, is phosphorylated: pyridoxal phosphate: b6-pi: PLP a. It is the aldehyde group on top of the ring 1) 2) Know active region of this molecule: i. Used as a cosubstrate b. Amino acid metabolism i. AA1+ Carbon Skeleton2--> transfer of amino group from AA to carbon skeleton and produce Carbon Skeleton1+ AA2 1) Amino group attacks aldehyde, forms intermediate called schiff base, carbon skeleton gets kicked out as a ketone, leave behind nitrogen attached to b6. 2) Transaminase ii. Over 100 enzymes use b6 c. Vitamin B6: Pyridoxal II. BIBC 120 Page 2
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B6 shuttles amino group btwn AA and carbon skeletons a) d. RDA: 1.3-1.7 mg/day i. Nerve damage 1) UL: 100 mg/day: much greater RDA ii. Dermatitis 1) Anemia 2) Convulsion 3) Deficiency iii. B6
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This note was uploaded on 06/03/2010 for the course BIBC bibc 120 taught by Professor Crawford during the Spring '08 term at UCSD.

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nutrition lecture notes 2 - 12 Tuesday, May 11, 2010 10:56...

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