CH. 13 POWERPOINT.pptx - Chapter 13 Nonopioid Analgesics Salicylates and Nonsalicylates Copyright \u00a9 2014 Wolters Kluwer Health | Lippincott Williams

CH. 13 POWERPOINT.pptx - Chapter 13 Nonopioid Analgesics...

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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 13 Nonopioid Analgesics: Salicylates and Nonsalicylates Chapter 13 Nonopioid Analgesics: Salicylates and Nonsalicylates
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Pain Pain Pain is the unpleasant sensory and emotional perception associated with actual or potential tissue damage The sensation of pain is sent from the peripheral tissue to the brain where it is interpreted. Pain medications change the sensation in the tissues or modulate the signal in the brain Acute pain has a short duration of less than 3 to 6 months, whereas chronic pain lasts more than 6 months
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Salicylates Salicylates Drugs derived from salicylic acid o Useful in pain management due to analgesic, antipyretic, and anti-inflammatory effects
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Salicylates: Actions and Uses Salicylates: Actions and Uses Lower body temperature Inhibit production of prostaglandins Aspirin: inhibits prostaglandin synthesis and has greater anti-inflammatory effects Prolongs bleeding time Used for mild to moderate pain; reducing elevated body temperature; treating inflammatory conditions; decreasing risk of myocardial infarction; reducing risk of transient ischemic attacks
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Salicylates: Adverse Reactions Salicylates: Adverse Reactions Gastrointestinal (GI) reactions: o Gastric upset; heartburn; nausea; vomiting; anorexia; GI bleeding ; allergy o Significant blood loss o Allergy to salicylates manifested by: Hives, rash, angioedema, bronchospasm, anaphylactoid reactions
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Salicylates: Contraindications and Precautions Salicylates: Contraindications and Precautions Contraindicated in clients with: o Known hypersensitivity; bleeding disorders; children or teenagers with chickenpox or influenza. Reye’s disease Used cautiously in clients: o With hepatic and/or renal disease; during pregnancy and lactation; with pre-existing hypoprothrombinemia; with vitamin K deficiency ; with GI irritation or peptic ulcer; with mild diabetes or gout
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Salicylates: Interactions Salicylates: Interactions Interactant drug Effect of interaction Anticoagulant Increased risk for bleeding NSAIDs Increased serum levels of the NSAID Activated charcoal Decreased absorption of the salicylates Antacids Decreased effects of the salicylates Carbonic anhydrase inhibitors Increased risk for salicylism
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Copyright © 2018 Wolters Kluwer · All Rights Reserved Nonsalicylates: Actions and Uses Nonsalicylates: Actions and Uses Actions: o Analgesic and antipyretic activity: same as salicylates o No anti-inflammatory action Uses: o Used to treat mild to moderate pain; reduce elevated body temperature; manage pain and discomfort—arthritic disorders
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Copyright © 2018 Wolters Kluwer · All Rights Reserved ASPIRIN PRODUCTS: ASPIRIN PRODUCTS:
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Copyright © 2018 Wolters Kluwer · All Rights Reserved
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Copyright © 2018 Wolters Kluwer · All Rights Reserved
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