Bio Study Sheet

Bio Study Sheet - Bio Study Sheet Genetic Disorders...

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Bio Study Sheet Genetic Disorders Single-Gene Disorders Autosomal Dominant: only one mutated copy of the gene is needed to be affected by the disorder. Often have low penetrance, so few develop the disorder and typically later in life. Examples: Huntington’s, Neurofibromatosis 1, and Hereditary nonpolyposis colorectal cancer. Autosomal Recessive: Two mutated copies necessary, unaffected persons are known as carriers. Two unaffected carriers have 25% chance of having a child affected by the disorder. Examples: Cystic fibrosis, sickle cell anemia, Tay-Sachs disease, Spinal muscular atrophy, and muscular dystrophy. X-linked dominant: The sons of a man with this type will not be affected, but his daughters will inherit the condition. A woman with this type has a 50% chance of having an affected son or daughter. Examples: Aicardi Syndrome, Klinefelter, and Hypophosphatemia X-linked recessive: Males are more frequently affected, a man with this type will not pass it on to his sons, but his daughters will be carriers. A woman with this type has a 50% chance of having affected
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Bio Study Sheet - Bio Study Sheet Genetic Disorders...

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