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Initiation_of_Infection_I_2009

Initiation_of_Infection_I_2009 - VI 1 Surfaoeiusion> G.p...

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Unformatted text preview: VI 1. Surfaoeiusion __.> G .._.p MW” f manhunt; ILEflmmEEE $Em§ ' y —+ mmmm awmd emwme —* mwmfi FIG. 4. Pathways for viral entry of the has Figure 5.|7 Stepwise uncoating of adenovirus. (A) Adenoviruses bind the cell receptor via the fiber protein. Interaction of the penton base with an integrin receptor leads to internalization by endocytosis. Low pH in the endosome causes destabilization of the capsid and release of protein VI. The hydrophobic N terminus of protein VI disrupts the endosome membrane, leading to release of a subviral particle into the cytoplasm. The capsid is transported in the cytoplasm along microtubules and docks onto the nuclear pore complex. Cell surface binding fiber// receptor lntegrin Endosome Acidified : endosome / Acid-dependent penetration ' ' 3 \Jncozting _ r ' >3545 min f, \ K ,r Binding to nuclear pore complex Initiation of Infection -| G C.E.Samum MCDB134 ""0“"5-51— m . §3°e~2§~33 Eg§l25=t3<a~ ,U._Sm::12~| fluaoeuamvh .Eg230:_<2 in- Um.mN-u -H'F‘ nu). . ._ :1 u ___¢=~o 3§E=§52>2~1 oowfigkzufiqV U>~hunqnfiz§a“ EBD'Si-E.:F‘:““ “220w“we23” “UN—C'GEGGHL 3 >~~c. 2:. u"- LU~-moD—EH>% "Emc In >0“ 0855...... Que oy> tau~~fia;a‘ oufiafioguw“ Ba=02“2~‘fi- mom i: :3: “‘E‘a‘><U°-U.H£-E éseéfifigsge —~Uu—4_=HD-°W‘Uk EU=VIO0 «54:02 o>‘w::“-umE m’o“=o°u=o‘ *££M£U;Em<. o$EE“u“:° : o “M .0'50 U NW'UH._c.—. EWES~ 5:“63 «E's-~EUnr—O '- H V} -v-‘ UHSE C Came-1:9 “Emmflaueflflz *W.£V;8"S'EQ’§§D- fiEme~>mum : m.;gga~uu-;8.‘= 2:58u£§%823 u . ag§§5~§ts§g ILmuuQE‘E‘E'EES Coated vesicle Early endos’ome‘ui' A (pH <’ 6.2) ‘ Capsid exposed to cytoplasm Late endosome (pH < 5.3) Capsid disassembly ' l a? I i: :2 aefi‘auaéggnmy‘g‘ owwm—5°"§ga—Eo 9 3 8 u 0 a O . a 8 ‘E'E-E a 5'55: 3591 e 53.0 4::‘5i‘giaab . =v§gm°g o "'5'“ 0 o a 5 E v u‘3 4: u o 5 ? ”9“§‘e€a“ 5e "i fiofifivuég "335‘ VEUEjEEz'gfimu-u—Q'g wee—.maeaégggu E §832§5“°’°$%mqm Y . | onngog‘EE-aeuang‘ Virus Attachment to Host Cel s E. 8 3 m 5’ a a E .2 % 8 ‘5 q a u: ‘6 8 a .3 8 , o S E . / a E ,5 .2: Table 4.l Vlral receptors and coreceptors 8 E 9 Virus Receptor Type of molecule 3 _ . . z u, 3 Ptcornavzrtdae 20 g 8 Foot-and-mouth disease virus Heparan sulfate Glycosammoglycan Z 2 (cell culture adapted) F g . E Foot-and-mouth disease virus (1J3, (vitronectin receptor) Integrm ‘5 g 2 Eg; Encephalomyocarditis virus Vcam-l lg-like E g g < 8. Sialylated glycophon‘n A (for hemag- Carbohydrate '> I a 2 g glutination only) E E § Poliovirus type 1 to 3 Pvr Ig-like o g g g - o . I" l V ’ ' m 2 .- Hepatitis A Virus HAVCr-l Ig-like, mucin-like E :3 78E Major group rhinoviruses Icam-l Ig-like 2 A c m (91 serotypes) m '8, a ' o Rhabdovz‘ridae g m .E a; Rabies virus Nicotin'ic acetylcholine receptor Neurotransmitter receptor a fig a: . .. N Neural cell adhesion molecule CD56 Ig-llke ill: 3 N 5 Low-affinity nerve growth factor receptor Tnf receptor protein superfamily (g) a: o > Paramyxaviridae E o. 8 Measles virus Membrane cofactor protein, CD46 Complement-regulating protein ' E 2 5 Sendai virus Sialic acid Carbohydrate E «3% Asialoglycoprotein receptor Gp-2 Transport protein (receptor- —, g 8 o - - > o 2 9 mediated endocytosts) E Orthomyxoviridae é Influenza A and B viruses Sialic acids (N-acetyl neuraminic acid) Carbohydrate Influenza C virus Sialic acids (9-0-acetyl neuraminic acid) Carbohydrate Reaviridae Reovirus Sialic acids Carbohydrate Group A porcine rotavirus Sialic acids Carbohydrate Retroviridae - . Human immunodeficiency CD4 Ig-like Chemokine receptors virus type 1 ~ (Cch, Cxcr4, Ccr3) ' . Galactosylceramide Glycolipid l Papovaviridae ’ ‘ Simian virus 40 Major histocompatibility class I molecule Ig—like Adenoviridae Adenovirus subgroups A, C, Car Ig-like “v integrins D, E, F 4 Herpesviridae ' . Herpes simplex type 1 Heparan sulfate Glycosaminoglycan HveA, Prrl Herpes simplex type 2 Heparan sulfate Glycosaminoglycan HveA, Prrl, Prr2 Pseudorabies virus Heparan sulfate Glycosaminoglycan Pvr, Prrl, Prr2 Bovine herpesvirus 1 Heparan sulfate Giycosaminoglycan Pvr, Prrl Human herpesvirus 7 CD4 lg-like Epstein-Barr virus Complement receptor Cr2 (CD21) SCR-like (complement cascade) Human cytomegalovirus Heparan sulfate Glycosaminoglycan Aminopeptidase N (CD13) Poxviridae Vaccinia virus Heparan sulfate Glycosaminoglycan Epidermal growth factor receptor Signaling receptor '1' he name of the receptor and the type of molecule are listed for selected viruses. When coreceptors have been identified, the tor column indicates that none have been identified to date. Abbreviations: Vcam, vascular cell adhesion molecule; Prrl, PrrZ, Pvt-related proteins 1 and 2: SCR, short consensus repeat; lg. immunoglobulin: Tnf, tumor necrosis factor; Carl, cytopathic avian leukosis and sarcoma virus receptor; ar, coxsackievirus and adeno- virus receptor; HveA, herpesvirus entry mediator. F]; “1‘3 E it g“ (5.} I Kn“?! Ra CE rug/fig} Skogka pvt/g 14059“) J y are listed: a blank in the corecep< ...
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