Week_2_2008_Racaniello_Answers

Week_2_2008_Racaniello_Answers - Transgenic mice expressing...

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Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis Vincent R. Racaniello MCDB 134 week 2 discussion
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Make up assignment for those who missed section (you can only do one make up assignment this quarter) This make up paper should be one to two pages. Summarize the important information from this paper highlighting the topics in this presentation, including the methods used, the results of the experiments and conclusions reached by the authors. Be sure to emphasize the goal of the research and the extent to which the goal was reached.
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Background Poliovirus – Family picornaviridae – (+) ssRNA – Causes paralytic poliomyelitis in primates – Cell and tissue tropism restriction is determined by presence of absence of the Polio virus receptor (PVR) a novel member of the Ig superfamily. – The natural disease course in humans; • ingestion of the infectious virions which multiply in the lymphoid tissue of the digestive tract. • in some cases the virus progressively moves to the neural tissue including the spinal cord and motor neurons resulting in paralysis.
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• Previous poliovirus research in animals was conducted in chimpanzees. – Acquisition and care of the animals is very costly. • It is better to develop a mouse system in terms of costs and logistics. • Two human poliovirus receptor genomic clones isolated: PRG1 and PRG3. • Used to make transgenic lines TgPVR1 and TgPVR3.
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Week_2_2008_Racaniello_Answers - Transgenic mice expressing...

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