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9_1_Herpesvirus

9_1_Herpesvirus - ‘ C EMSamuel v MCDB 134...

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Unformatted text preview: ‘ C. EMSamuel v _ . MCDB 134 Herpesvirldae (herpes sm‘lplex VII'US) . V ' TABLE 1. Viruses of the family herpesviridae‘ ‘ Vernacular name ‘ . _‘ Genome Designation (synonyms) Subfamily %(G+C) Group size (kbp) Abbreviation Viru5es of humans ' Human herpesvirus 1 Herpes simplex virus . at 68.3 E 152 , HHV-1 Human herpesvirus 2 Herpes simplex virus 2 ' a 69 E 152 HHV-2 Human herpesvirus 3 - Varicella-zoster virus 0!. , 46 . D 125 HHV-3 Human herpesvirus 4' Epstein-Barr virus y . ‘ 60 C 172 HHV-4 Human herpesvirus 5 Cytomegalovirus y 57 E 248 ‘ HHV-5 Human herpesvirus 6A B 43 A 159/170 HHV—6A Human herpesvirus BB C B 43 A 162/168” HHV-GB Human herpesvirus 7 ‘ B 36 A 145 l HHV-7 ' Human herpesvirus 8 . Kaposi’s sarcoma- y . 59 C 170/210” HHV-8 associated herpesvirus . I ' ' ' ct‘ : 2. Secondar sit ot'inlection ‘ ‘ 1 icgzifitrgfiileeinoffeglgn ’gfn ‘ and site o¥lat§nt infection; epithelial cells - sensory neurbn M" ‘ m 4* . , I a l E Infection by Viral DNA in. ‘; '< E retrograde latent state a” Z ‘1 transport w o E D .5 a: To U) i s 8 .C E — g a. I it "' c S E .‘: q) _ Reactivation by ‘5 o "8 _. E 4|" u, .w '5 anterograde , 0.: :>2323 transport 3 ‘ ()1 N % ':.: .D 2 2 (Cu m a: m u 3 o o c e: N c: ‘- . a O “I o :1 :: -— o E .39 2 .‘E E 5 o z z E z y :0 ~ sensory E < g; ‘ v ganglion 7: § 2 3 3. Site of recurrent infection: , g 2 D E productiv Infection of ’ g 2 E g epithelial ells ‘E 5 '5 a = 0‘, m ‘0 .. .: a) g 'c 5 E S > E” l E '2 E 3 g D M 5 FIG. 11. Stages of HSV infection of the host. 1. HSV is introduced onto a mucosal surface or a break 0 . g 8 a, 5 £ '3‘ .03 3 . in the skin; it replicates productively in epithelial cells at the site ol inoculation and spreads'throughthe ,_- ~— 8 Cl 2; E, E‘ 'E 8 E tissue. Virus enters sensory neuron axons and is transported to the cell body In a ganglion. 2. Virus u', 0 - g :3 8‘ 3 D ~55 either replicates productively or establishes a latent infection In the neuronal cell nucleus. Viral DNA'IS , m E E > f: m '5 Q = I: circular and in a nucleosomal form. Upon neuronal damage or activation, the Vlt'US reactivates‘and I“ >. GE, 3 4:, E 3 - -- g g undergoes at least a limited productive cycle. Capsids are transported by anterograde transport to the 33' E a, E E E g %’ g g 2 E - axonal termini and virions are released. 3. Reactivated virus causes a recurrent Infection of the mucosal :2 w 5 a; .9 3 2: 9:3 5 g 8 ' tissue, causing the shedding ofvirus. ' u. . .1 . ~ _ . PERCENT OFIPATIENTS _ W \x \ 0-12 12-24 24-36 36-48 48-60 50-72 4 5 6-7 8-10 HOURS - TlME AFTER INFECTION FIG. 4. Course of recurrent herpes labialis lesions. (From ref. 316, with permission.) ...
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