Week_9_2009_SARSAnswers

Week_9_2009_SARSAnswers - Make-up assignment Write a 1-2...

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Unformatted text preview: Make-up assignment Write a 1-2 page summary of the SARS paper where they identified the etiologic agent that was the cause of SARS. Include in your paper the following: 1) Define SARS 2) Describe the initial methods used to identify the virus and what was found in those studies. 3) Describe how identification and isolation of the virus enabled design of serological and molecular techniques for testing for the presence of the virus in patient samples. Announcements Midterm #1 I have the regrades (if you have not gotten it back). Midterm #2 Re-grades are due next Wednesday (June 3) at noon . Some exams have been xerocopied Quiz #2 is coming up next week!!! Absolutely come to the section you normally attend. We will talk more about what to study, etc. in a minute. Quiz #2: Format and What to Study Format: Fill-ins Short answer Problems How to study: Understand the questions in the PPT presentations (posted with answers on Gauchospace) Dont forget to pay attention to background introduction to each paper Try the practice problems Come see me in my office hours if you feel you need help ( Wed 2~3PM; Thr 2~3PM ) An example for a complete answer: whats the size of exons and introns and S1 digestion ExoVII digestion-S1 is endonuclease and exonucleuase-ExoVII is an exonuclease and possesses no endonuclease function-Therefore the size of the intron: ssDNA ssDNA mRNA mRNA minus equal When you answer the question you need to write out the whole process in English, dont show me the pictures only, I will take off at least half credits if so. If you want to draw the picture at least indicate with appropriate explanation. why? Nov 2002 July 2003 From China to 28 countries Highly contagious Mortality rate ~10% SARS S evere A cute R espiratory S yndrome Disease agent: a novel coronavirus Source of the virus: may have acquired it from animals sold in markets (i.e. civets) but that the natural hosts are bats Asian palm civet Chinese horseshoe bat Coronaviridae Corona = crown (latin) Virions: Enveloped Distinctive crown morphology Spike protein: major attachment protein, club shaped protein that can easily be seen by EM ---- the crown Genome +ssRNA, linear, helical nucleocapsid ~20-30kb Responsible for ~1/3 of common colds 3 groups (I, II, III) based on genetic and antigenic properties 2 human coronaviruses: 229E, OC43 International multidisciplinary efforts were made to identify this etiologic factor Question #1: What was the goal of this paper? Question #1: What was the goal of this paper? Answer: Question #1 The goal of this paper was to identify the etiologic agent that causes SARS. Scheme for Isolating SARS Etiologic Agent B ioS afty L evel 3 environment required Collecting diseased materials Collected clinical specimens included: blood, serum, materials from oropharyngeal swabs or washings, materials from nasopharyngeal swabs,...
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This note was uploaded on 06/08/2010 for the course MCDB 134 taught by Professor Samuels during the Spring '10 term at UCSB.

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Week_9_2009_SARSAnswers - Make-up assignment Write a 1-2...

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