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10_1_Vaccines_1

10_1_Vaccines_1 - C E Samuel Vaccines ‘ MCDB 134 ®...

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Unformatted text preview: C. E. Samuel Vaccines . ‘ MCDB 134 ® ’“ @ Virus infects vertebrate J Humoml Immune Response Cell-mediated Immune Response ¢ Upiake of aniigam antibody complexes » by scavenger whim ” blood cells Killed virus vaccine 800 7N T M u 500 c 4 a - 2° °° — g , 3“" g h 10 20° g E 1th,; ' ? é a, 0.5 1 ' i Live virus vaccine 3 70 160 g 3 so ‘ 140 2 ‘ g 50 120 g 5 40 mo 2 , 3° 80 60 20 10 038 0 W.Wm 1950‘ 1960 1970, , 1980,1969 1980 1970 1980 Pic. 9-5. Thefall in theincidmce afpoll'amyelitis, measles. rubella, and mumps in the timid States following the intradudion of vaccinah'On against these diseases (arrows). 1W potiavims vaccine was introduced in 1954; live vaccine in 1963. The other 517‘; "Wish: (1963), mumps (1967), and rubella (1969), are all live vaccines (see Figure I92 Comwison of the predicted immune ream :0). (Co ”led in data Id 511 lid ' the Centers Disease Control, sponses to live and killed viruses used In mcine protocoli. W States.) mp: fm ndly PP by for Immune response ——> Comparison of immune responses to live and killed viruses ‘But no.5: ‘But so ‘151'. ifdalivaradivia on! from multiplying in the 'MgCl, and othé: stabilizers, IEtpadally in Tli'ml World” ” Table l9.2 Viral vaccines licensed in the United States“. Disease m vi: us Hepatitis A Polio (inactivated) Polio (live) Yellow fever Rubella Japanese encephalitis Influenza Measles Mumps Rabies Hepatitis B Adenovirus Varicella prt <15 water into Inactivated whole virus Inactivated whole viruses of types 1, 2. and 3 Live attenuated oral mixture of types 1, 2, and 3 Live attenuated Live attenuated Inactivated whole virus Inactivated, viral subunits Live attenuated Live attenuated Inactivated whole virus Yeast-produced recombinant surface protein Live attenuated oral Live attenuated thfactnryadjuvantsyatlioensadforhumanuse «respiratory route. OPV cantfi‘araby prevant’m'ldpoflovlms gut hence Editing nae mdhfionoffiwvnmfiomflle' Indmntiun» For use Travellers, other high-risk groups Universal vaccination of infants Universal vaccination have] in areas where infection is CDmanfl Universal vaccination of infants Travelers or inhabitants of high-risk areas in Asia Elderly and other high-risk groups Universal vaccination of infants Universal vaccination of infants a Exposure to rabies, actual or prospective Universal in children. exposure to blood, sexual promiscuity Military recruits Universal vaccination of infants Smallpox Live vaccinia virus ‘ Certain laboratory workers 'Adapted from D. D. Richman at al., Clinical Virology (Churchill Livingstone, New York, N.Y., 1997), with permission. ’MMR, measles-mumps-mbella. ...
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