Endocrine System

Endocrine System - The Endocrine System Assigned reading:...

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The Endocrine System Assigned reading: Chapter 15
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Objectives: 1. Know the differences in structual classifications of hormones and how they signal to other cells 2. Understand how hormones travel between cells 3. Explain the relationship between the hypothalamus and the anterior pituitary 4. Describe the factor triggering hormone release and the body’s response to each hormone in the body
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The Endocrine System Target cells Endocrine cells Hormone in bloodstream
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Structural Classifications of Hormones Amino Acid-Based Steroid Eicosanoids
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What are the Mechanisms of Hormone Action? Alter plasma membrane permeability Stimulate protein synthesis Regulate enzyme activity Induce secretion Stimulate cell division How do hormones do all of these things?
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Cyclic AMP Second Messenger Signaling
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Cyclic AMP Second Messenger Signaling Summary: Hormone binds receptor G-protein activated Adenylate cyclase activated cAMP levels rise Protein kinase A activated PKA-responsive enzymes, ion channels, secretory pathways, etc. are activated
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PIP Second Messenger Signaling
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PIP Second Messenger Signaling Summary: Hormone binds receptor G-protein activated Phospholipase C activated IP3 generated, releasing Ca +2 DAG generated Ca +2 binds Calmodulin Protein kinase C activated PKC- and Calmodulin-responsive enzymes, ion channels, secretory pathways, etc. are activated
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Intracellular Receptors/ Direct gene activation Hormone binds receptor Complex modulates transcription New genes expressed New cellular structures/behaviors
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Endocrine System - The Endocrine System Assigned reading:...

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