web_L27_10BIO311C - BIO 311C Spring 2010 Lecture 27 Monday...

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BIO 311C Spring 2010 Lecture 27 – Monday 5 Apr. 1
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Metabolic Pathways and Processes that Participate in Respiration - Glycolysis - Pyruvate dehydrogenase - Krebs Cycle - Mitochondrial electron transport chain - Oxidative phosphorylation Occurs in the cytoplasmic matrix Occur in mitochondria of eukaryotic cells 2 Review *
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Reactants and Products of Glycolysis Review 3 *
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Some Alternative Possible Fates of the Pyruvate Generated During Glycolysis * glucose 2 ATP glycolysis 2 NADH 2 pyr food fermentation products respiration products - Pyruvate may serve a a food source for making bigger and more complex molecules, using anabolic pathways. - Pyruvate may be chemically reduced by fermentation in one of more reactions that regenerate NAD + from NADH. - Pyruvate may serve as a fuel by continuing respiration, using catabolic pathways. 4 regeneration pathway
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An Example of Pyruvate Used as a Food (Building Material) pyruvate * alanine (an amino acid) 5
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Comparison of Chemical Equations for Fermentation and Glycolysis * The equations for fermentation and glycolysis look similar, except that in fermentation no hydrogen atoms are released (i.e. there is no net oxidation of substrate). Fermentation written as a single equation Glycolysis written as a single equation (2 pyr) 6
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An extended metabolic pathway that includes glycolysis plus one or more additional metabolic reaction that results in the chemical reduction of pyruvate or a substrate derived from it. glucose 2 pyr 2 ATP 2 NADH 2 pyr 2 NADH fermentation product (oxidized) (reduced) glycolysis additional metabolic reaction(s) * Definition: Fermentation - (reduced) Glycolysis Extending Reaction(s) (oxidized) 7
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Fermentation, shown as a single metabolic pathway glucose 2 pyr 2 ATP glycolysis 2 NADH fermentation products extending rx. The final fermentation product is often excreted from cells as waste.
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This note was uploaded on 06/11/2010 for the course BIO 48765 taught by Professor Sathasvian during the Spring '10 term at University of Texas at Austin.

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web_L27_10BIO311C - BIO 311C Spring 2010 Lecture 27 Monday...

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