Handout 7 - Lamins

Handout 7 - Lamins - M CB 252 Cell Biology, Spr ing 2008 H...

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Unformatted text preview: M CB 252 Cell Biology, Spr ing 2008 H andout 07 Heterochromatin Euchromatin Regulation of tr anscr iption: Chr omatin or ganization... M CB 252 Cell Biology, Spr ing 2008 H andout 07 r ibosome RER Cytoplasm nuclear por e complex per inuclear space outer membr ane inner membr ane nuclear lamina chr omatin Regulation of tr anscr iption: Chr omatin or ganization... M CB 252 Cell Biology, Spr ing 2008 H andout 07 Regulation of tr anscr iption: Chr omatin or ganization... The nuclear lamina is speculated to have two essential r oles: 1. I t pr ovides str uctur al suppor t to the nuclear envelope, giving shape to the nucleus with mechanical function. 2. I t contr ibutes to the or ganization of the heter ochr omatin at the inner nuclear membr ane, and was implicated in r egulating the expr ession of cer tain genes (DN A r eplication and RN A splicing). M CB 252 Cell Biology, Spr ing 2008 H andout 07 Regulation of tr anscr iption: Chr omatin or ganization... The nuclear lamina is a filament meshwor k that lies beneath the inner nuclear membr ane. M CB 252 Cell Biology, Spr ing 2008 H andout 07 Regulation of tr anscr iption: Chr omatin or ganization... These filaments of the lamina meshwor k ar e polymer s of pr oteins named Lamins, which ar e member s of the inter mediate filament pr otein (type V) family. Dimerization Higher-ordered assembly nuclear targeting membrane targeting N C N C M CB 252 Cell Biology, Spr ing 2008 H andout 07 Regulation of tr anscr iption: Chr omatin or ganization...or ganization....
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Handout 7 - Lamins - M CB 252 Cell Biology, Spr ing 2008 H...

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