Handout 7 - Lamins - M CB 252 Cell Biology Spr ing 2008 R...

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MCB 252 Cell Biology, Spring 2008 Handout 07 Heterochromatin Euchromatin • Regulation of transcription: Chromatin organization...
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MCB 252 Cell Biology, Spring 2008 Handout 07 ribosome RER Cytoplasm nuclear pore complex perinuclear space outer membrane inner membrane nuclear lamina chromatin • Regulation of transcription: Chromatin organization...
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MCB 252 Cell Biology, Spring 2008 Handout 07 • Regulation of transcription: Chromatin organization... The nuclear lamina is speculated to have two essential roles: 1. It provides structural support to the nuclear envelope, giving shape to the nucleus with mechanical function. 2. It contributes to the organization of the heterochromatin at the inner nuclear membrane, and was implicated in regulating the expression of certain genes (DNA replication and RNA splicing).
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MCB 252 Cell Biology, Spring 2008 Handout 07 • Regulation of transcription: Chromatin organization... The nuclear lamina is a filament meshwork that lies beneath the inner nuclear membrane.
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MCB 252 Cell Biology, Spring 2008 Handout 07 • Regulation of transcription: Chromatin organization... These filaments of the lamina meshwork are polymers of proteins named Lamins, which are members of the intermediate filament protein (type V) family. Dimerization Higher-ordered assembly nuclear targeting membrane targeting N C N C
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MCB 252 Cell Biology, Spring 2008 Handout 07 • Regulation of transcription: Chromatin organization...
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