Handout 9 - Regulation of Transcription -...

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MCB 252 Cell Biology, Spring 2008 Handout 09 • Regulation of transcription: Chromatin dynamics Deacetylated histones Acetylated histones HATs HDACs
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MCB 252 Cell Biology, Spring 2008 Handout 09 HATs have been identified from yeast to man (low-high eukaryotes) and are conserved  ATP dependent acetyle transferases. The first acetyltransferase identified in yeast was the TF  Gcn5 , a transcriptional co- activator. Others now identified include;  CBP  (CREB binding protein),  PCAF  (CBP-associated  factor),  hTAFII250 TFIIIC  (activation by RNAPIII),  SRC1  (steroid co-activator). They are recruited to promoter regions by DNA binding activators. Histone Acetyl transferases (HATs) and transcriptional activation: • Regulation of transcription: Chromatin dynamics
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MCB 252 Cell Biology, Spring 2008 Handout 09 • Regulation of transcription: Chromatin dynamics
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MCB 252 Cell Biology, Spring 2008 Handout 09 Histone Deacetylases (HDACs) and transcripitonal repression • Yeast have two major HDAC complexes (each have at least
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