Handout 10 - Post-transcriptional Regulation

Handout 10 - Post-transcriptional Regulation - MCB 252 Cell...

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MCB 252 Cell Biology, Spring 2008 Handout 10 I. The Cellular Periphery and Its Role in Controlling Gene Expression I. Transcriptional Control of Gene Expression I. Translational Control of Gene Expression a. Small RNA Mediated Translational Control a. Protein Mediated Translational Control b. Post-Translational Protein Modification c. Regulated Protein Degradation of Essential Cellular Factors: Cancer Therapy d. Prions and neurodegenerative diseases
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MCB 252 Cell Biology, Spring 2008 Handout 10 New questions: How is the expression of a gene regulated at the transcriptional level? How is the expression of a gene regulated at the post- transcriptional level? How are mRNAs exported to the cytoplasm? What regulates protein homeostasis? III.a. Small RNA Mediated Translational Control
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MCB 252 Cell Biology, Spring 2008 Handout 10 Cytoplasm Nucleoplasm Export Chromatin pre-mRNA processing Transcription pre-mRNA Capping AAAAA Cleavage and Polyadenylation Me AAAAA Splicing mRNA Me • Post-transcriptional regulations Gene
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MCB 252 Cell Biology, Spring 2008 Handout 10 III.a. Small RNA Mediated Translational Control Phosphorylated tail that recruits capping machinery
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MCB 252 Cell Biology, Spring 2008 Handout 10 Transcription elongation Chromatin PolII • Post-transcriptional regulations Ribonucleoprotein particle RNA binding proteins PolII Cap binding complex
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MCB 252 Cell Biology, Spring 2008 Handout 10 Transcription elongation Chromatin • Post-transcriptional regulations PolII intronic sequence PolII splicing machinery (spliceosome)
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MCB 252 Cell Biology, Spring 2008 Handout 10 Transcription elongation • Post-transcriptional regulations Chromatin PolII AAAUAA G/U Poly A tail 3’ PolII
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MCB 252 Cell Biology, Spring 2008 Handout 10 • Post-transcriptional regulations Poly A tail is ~250 residues 3’ poly A binding protein II (PABPII) 1 PABPII for 12 A residues RNP particle RNA Proteins
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MCB 252 Cell Biology, Spring 2008 Handout 10 Cytoplasm Nucleoplasm Export Chromatin pre-mRNA processing Transcription pre-mRNA Capping AAAAA Cleavage and Polyadenylation Me AAAAA Splicing mRNA Me • Post-transcriptional regulations Gene
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MCB 252 Cell Biology, Spring 2008 Handout 10 • Post-transcriptional regulations
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Handout 10 - Post-transcriptional Regulation - MCB 252 Cell...

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