Handout 11 - MCB 252 Cell Biology, Spring 2008 mRNP...

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MCB 252 Cell Biology, Spring 2008 Handout 11 mRNP particle Rapid degradation (non sense mediated decay) were all the EJC removed? No Yes Degradation Translation Specific sub-cellular distribution. Inhibition of translation. Translation signal Global repression: no growth factors or viral infection for example Specific repression
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MCB 252 Cell Biology, Spring 2008 Handout 11 Polyribosomes (Polysomes) The rate of deadenylation varies inversely with the frequency of translation initiation for an mRNA
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MCB 252 Cell Biology, Spring 2008 Handout 11 eIF2 is a small GTPase
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MCB 252 Cell Biology, Spring 2008 Handout 11 GDP + Pi eIF1A, eIF3 and the eIF4 complex (ATP ADP + Pi)
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MCB 252 Cell Biology, Spring 2008 Handout 11 Translation starts
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MCB 252 Cell Biology, Spring 2008 Handout 11 eIF2 GTP eIF2 GDP On state Off state Translation Start (GAP) Initiation complex at the AUG codon (GEF) eIF2b
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MCB 252 Cell Biology, Spring 2008 Handout 11 eIF2b GTP eIF2 GTP eIF2 GDP eIF2b eIF2 eIF2b GDP Pi Thus, eIF2b is critical to initiate translation translation starts
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This note was uploaded on 06/12/2010 for the course MCB 252 taught by Professor Prasanth during the Fall '08 term at University of Illinois at Urbana–Champaign.

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Handout 11 - MCB 252 Cell Biology, Spring 2008 mRNP...

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