unused slides - handout 6 - Genes - core promoter...

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Unformatted text preview: Genes - core promoter & GTFs IID IID IID IIB IIB IIE, IIH, PolII IIA TF IIA, IIB, IID, IIE, IIF and IIH, and RNA polymerase II General Transcription Factors (GTFs) } TATA box TFIIB Recognition Element Initiator Downstream Core Promoter Element TFIIB-RE DPE Initiator TATA box-38 -32 -26 +1 +30 PolII is a protein complex composed of 12 subunits Genes - core promoter & GTFs Carboxyl Terminal Domain Y S P T S P S T S P S T S P S Y S P Y S P P TS P S Y S S P S Y S P T Y S P T S P S Carboxyl Terminal Domain (CTD) Genes - core promoter & GTFs Multiple repeats of the peptide YSPTSPS (26 in yeast, 52 in mammals) YSPTSPS 1 2 3 4 5 6 7 Phosphorylation sites Y S P T S P S T S P S T S P S Y S P Y S P P TS P S Y S S P S Y S P T Y S P T S P S CTD phosphorylation regulates transcription initiation and elongation, and promotes interaction with other factors involved in transcription and splicing. Genes - core promoter & GTFs The RNA pol II holoenzyme....
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This note was uploaded on 06/12/2010 for the course MCB 252 taught by Professor Prasanth during the Fall '08 term at University of Illinois at Urbana–Champaign.

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unused slides - handout 6 - Genes - core promoter...

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