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Handout 1,2 - Cell Motility - MCB252CellBiology,part2...

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MCB 252  Cell Biology, part 2 Prof. David Rivier Office hours:  Mondays 2-3:30, MCB Learning Center Wednesdays 2-3:00, MCB Learning Center
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MCB 252, part 2 Course outline   Cytoskeleton, cell motility  Cell-cell adhesion, cell-ECM interactions   Cell cycle regulation  Cancer
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Organs and  Tissues Multi-cellular organisms form tissues and organs: specialized  structures Bissell, 2003
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Organs and Tissues What properties do cells in tissues need to have in order for the  organ/tissue to function properly? Bissell, 2003
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Cells within a  Tissue Alberts 23-12, 23-16, 23-20
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Cells within a tissue Alberts 23-7 Alberts 23-1 Cells in a SOCIAL CONTEXT
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Stem Cells Alberts 23-5
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Cells typically undergo several steps leading to  terminal differentiation
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Four Global Responses to Signals Cells in a social context: most signaling is from cells to each other. Alberts 15-8
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Four Global Responses to Signals Alberts 15-8 Adhesion property A Cytoskeleton arrangement A  Adhesion property B Cytoskeleton arrangement B 
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Properties of cells within tissues 1. Adopt defined shape 2. Express specific set of genes (differentiation) 3. Carry out specialized functions > terminally differentiated cells 4. Replace dead cells with new ones 5. Remain distinct from cells in neighboring tissues 6. Work together: adhere to each other 7. Work together: coordinate activity (part of adhesion) 8. Work together: communicate
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