Handout 6 - Regulation of Actin by proteins

Handout 6 - Regulation of Actin by proteins -...

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Actin Cytoskeleton Properties of Actin Actin assembly Role of ATP Treadmilling Role of acting in cell movement Actin is required for movement Actin assembly can drive movement Regulation of actin assembly in cells Proteins involved in actin assembly/disassembly Turning the protein involved in assembly and  disassembly ON and OFF Building stable actin structures
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3 main types of actin filaments involved in this type of  motion How does signaling set up and maintain cell polarity? Filopodia
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RAS superfamily Families often named for the first member identified Alberts Table 15-5
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Activation of Ras Family members is similar Signaling triggers activation GAP resets the signal making the response transient (doesn’t last very  long)
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Activated Rho triggers Formin activation Rho-GDP (inactive) until a signal is received
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Activated Cdc42 triggers WASp activation Activated WASp activates Arp2/3 complex and therefore  triggers branched polymer formation
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Coordinated Regulation of  Cdc42, Rac and Rho
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Coordinated Regulation of  Cdc42, Rac and Rho
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Handout 6 - Regulation of Actin by proteins -...

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