Handout 9 - Intermediate Filaments

Handout 9 - Intermediate Filaments - MCB 252, Part 2...

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Unformatted text preview: MCB 252, Part 2 Cytoskeleton I ntermediate filaments (I Fs) • Classes • Structure of monomer/polymer • Dynamics • Functions I ntermediate filament network in epithelial cells Albert s, et al., Fig. 16-18 Keratin ; Cell boundaries I Fs are extremely stable Pollard and Earnshaw, Fig. 35-4 Cell extracted with detergent, high salt, stained for I F L V PAGE I nter mediate Filament Classes Class I F type Distr ibution I Acidic keratin Epithelial cells I I Basic keratin Epithelial cells I I I Desmin, Vimentin, GFAP Muscle, mesenchymal cells, glia I V Neurofilaments, NF-L, NF-M, NF-H Neurons V Lamins Animal & plant nucleus VI Nestin Embryonic neurons I nter mediate filament str uctur e Pollard and Earnshaw, Fig. 35-2 Evolution of I F Super family Lamins were the progenit ors t o other I Fs • Arose in Animals aft er the branching off from plants • Lamins lost NL S and Prenylation region (membrane attachment) resulting in cytoplasmic localization. • Cyt oplasmic Lamins for med several families each with specific functions: skin, muscles, ner ves alpha-helical coiled coil Albert s, et al., Fig. 3-11 Lodish, Fig. 3-6c H ow can one deter mine the or ientation...
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This note was uploaded on 06/12/2010 for the course MCB 252 taught by Professor Prasanth during the Fall '08 term at University of Illinois at Urbana–Champaign.

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Handout 9 - Intermediate Filaments - MCB 252, Part 2...

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