Handout 11 - Microtubule Organizing Centers

Handout 11 - Microtubule Organizing Centers - MCB252Part2

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MCB 252 Part 2 
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Microtubule-organizing centers (MTOCs) Spontaneous polymerization/nucleation of MTs is highly unfavorable  – waste of energy. Cellular MTs arise from nucleation sites called microtubule-organizing  centers (MTOCs) 1) Centrosome (2 centrioles + PCM) 2) Basal Bodies
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Microtubule-organizing centers (MTOCs) Centrioles and Basal Bodies Lodish, Fig.  18-5 Cilia and  Flagella
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Specialized MT Structures found in  MTOCs, Cilia and Flagella
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Microtubule-organizing centers   (MTOCs) Basal bodies at base of cilia and flagella Pollard and Earnshaw, Fig.  41-12 Basal body Axoneme Basal body
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Basal Bodies are Nucleation Centers for Axoneme  Assembly Axoneme Basal Bodies Axoneme MTs are extensions Basal Bodies MTs Doublet extends from 2/3 MTs in Triplet Basal body caps and anchors minus ends of axoneme.
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Structure of cilia and flagella relation to basal body Lodish 18-29
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Centrosomes 1875 Flemming and Van Benedon First visualized cellular components: nucleus, centrosome,  Centrosome = body in the center (of the cell) Nucleate, cap and anchor minus ends of MTs
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Centrosomes = Spindle Poles
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Handout 11 - Microtubule Organizing Centers - MCB252Part2

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