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Handout 13 - MT Motor Proteins (Dyneins)

Handout 13 - MT Motor Proteins (Dyneins) - MCB252Part2...

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MCB 252 Part 2  Handout 13 MT Motor Proteins, part 2
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Kinesin- and dynein-mediated transport Lodish, Fig.  18-27 Kinesins = plus end directed motors Dyneins = minus end directed motors
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Dyneins Dyneins were purified based on similar ideas and assays used to study  myosins and kinesins Cloning of genes that encode dyneins revealed: 1) That they were substantially different than myosins and kinesins. 2) Dyneins have a domain that is part of the AAA ATPase  superfamily.  
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ATPase Evolution and Motor Head Evolution Kinesin heads distantly related to myosin heads Their ancestral progenitor gene predates the 3 domains of What are the properties of the AAA ATPase family members?
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3 Domains of Life
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Three Domains of Life Eukaryote Archaea Bacteria What was the progenitor of all three domains? LUCA = Last Universal Common Ancestor LUCA = 3.6 - 4.1 Billion years ago Age of the Earth ~ 4.5 Billion years old
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Structure of AAA ATPases 6 AAA ATPase domains form a Hexamer Sometimes 6 domains in one polypeptide (gene with repeated sequences), Sometimes 6 domains in six polypeptides A Heximeric Disk
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