Handout 20 - MCB252,Part2 CellcycleIV,Handout20...

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MCB 252, Part 2 Cell cycle IV, Handout 20 Lodish 20.3, 20.5 and 20.7 
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Overview of Cdk Activation Activation of Early S-Cdk START Some CDKs  activated by  cyclin production:  1, 2, (3) 1 2 3 4 Some CDKs initially in  an inactive form and  need to be activated:  5 Produce S-phase  cyclins but keep  the S-Cdk in an  inactive form Activation of M-Cdk Produce M-phase  cyclins but keep  the M-Cdk in an  inactive form
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S-Cdk Initially Inhibited by Sic1 Sic1 Inhibitor Degraded by Cell Cycle-dependent Ubiquitination Release from Inhibition Triggers G1-> S and Events of S-phase (DNA  Replication)
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CKI, Inhibition of S-Cdk, Activation by Proteolysis p27 = Sic1
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Roles of Ubiquitination and Protein Degradation APC Degrades  S- and M- cyclins Degrade G1 cyclins SCF Activates S-Cdk by Degrading Sic1 (a CKI)
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Biochemical and Genetic Pathway of S-Cdk Inhibition and Activation S-Cdk DNA  Replication Sic1 G1-Cdk
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Overview of Key Events in the Cell Cycle Lodish, et al., Fig.  20-34
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This note was uploaded on 06/12/2010 for the course MCB 252 taught by Professor Prasanth during the Fall '08 term at University of Illinois at Urbana–Champaign.

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Handout 20 - MCB252,Part2 CellcycleIV,Handout20...

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