Handout 2 - Corrected

Handout 2 - Corrected - MC 252 C lls & Tissue Fall 2009...

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Handout 2 I. The Cellular Periphery and Its Role in Controlling Gene Expression a. Physiology of the Plasma Membrane a. Carriers and channels of the plasma membrane b. Cell surface receptors c. Reception and Integration of signals I d. Reception and Integration of signals II I. Transcriptional Control of Gene Expression II. Translational Control of Gene Expression
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Handout 2
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Handout 2 How is a signal received and transmitted by a cell? I. a. Physiology of the Plasma Membrane
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Handout 2 I. a. Physiology of the Plasma Membrane Phospholipids are amphipathic or amphiphillic
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Handout 2
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Handout 2 1. Specific lipid components of the membrane are distributed asymmetrically between the two leaflets of membranes: flip-flop mechanism I. a. Physiology of the Plasma Membrane (Exoplasmic leaflet) (Cytosolic leaflet) 2. Phospatidylserine and apoptosis
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Handout 2 I. a. Physiology of the Plasma Membrane Fluidity Fluidity of the lipid bilayer depends on both its composition and temperature
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Handout 2 Labeling of membrane proteins with a Fluorescent reagent Photobleaching of a small area Fluorescence recovery overtime intensity time (s) F luorescence R ecovery A fter P hotobleaching FRAP Viewed by fluorescence microscopy
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Handout 2 Prasanth lab data
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Handout 2 Prasanth lab data
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Handout 2 Prasanth lab data
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Handout 2 I. a. Physiology of the Plasma Membrane
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Handout 2 • Biomembranes: structure and properties Some membrane proteins are made less mobile by interaction with elements of the cytoskeleton or of the extra-cellular matrix
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Handout 2 Cell can confine proteins and lipids to specific regions of the plasma membrane
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Handout 2 I. b. Carriers and channels of the plasma membrane Many transmembrane proteins cross the bilayer with a short α - helical domain. Glycophorin A
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Handout 2 - Corrected - MC 252 C lls & Tissue Fall 2009...

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