Handout 3 - MCB252Cells&TissuesFall2008Handout3 I. The...

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    Handout 3 I. The Cellular Periphery and Its Role in Controlling Gene Expression a. Physiology of the Plasma Membrane b. Carriers and channels of the plasma membrane c. Cell surface receptors d. Reception and Integration of signals I a. Reception and Integration of signals II I. Transcriptional Control of Gene Expression II. Translational Control of Gene Expression
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    Handout 3 New question: How are transcription factors (txfs), sequestered in  the cytoplasm, released to enter the nucleus? I. d. Reception and Integration of signals I
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    Handout 3 Regulates the activity of specific genes TF NLS= Nuclear Localization Signal hidden NLS TF P Transporter TF P exposed NLS TF P Kinase
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    Handout 3 Regulates the activity of specific genes Inhibitory subunit TF TF TF Transporter TF TF P Kinase
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    Handout 3 TF Destruction box 2 TF P Ubiquitin TF P Degradation of the inhibitory subunit TF free TF Ubiquitin is recycled 1 TF P free TF
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    Handout 3 Exterior Cytosol Nucleus NF- k B NLS Inhibitory Unit I-kB kinase Activated TNF receptor E3 ligase polyubiquitin chain degradation of I- k B regulation of target genes
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    Handout 3 New questions: How is a protein poly-ubiquitinated? How is a poly-ubiquinated protein degraded? How does a protein enter the nucleus? More generally, how is nucleo-cytoplasmic traffficking  regulated? I. d. Reception and Integration of signals I
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    Handout 3 How is a protein poly-ubiquitinated? Ubiquitin (Ub) is a small (76 amino acid) protein that folds into a 
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Handout 3 - MCB252Cells&TissuesFall2008Handout3 I. The...

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