Handout 4 - MCB252Cells&TissuesFall2009 Handout4 I. The...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
    Handout 4 I. The Cellular Periphery and Its Role in Controlling Gene Expression a. Physiology of the Plasma Membrane b. Carriers and channels of the plasma membrane c. Cell surface receptors d. Reception and Integration of signals I a. Reception and Integration of signals II I. Transcriptional Control of Gene Expression II. Translational Control of Gene Expression
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
    Handout 4 How is a poly-ubiquitinated protein degraded? New questions: How is a protein poly-ubiquitinated? How is a poly-ubiquinated protein degraded? How does a protein enter the nucleus? More generally, how is nucleo-cytoplasmic trafficking  regulated?
Background image of page 2
    Handout 4 How is a poly-ubiquitinated protein degraded? An oligo-ubiquin chain marks the target protein for destruction  without affecting the inherent stability of the protein In the absence of the destruction apparatus, proteins bearing the  signal is perfectly stable
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
    Handout 4 How is a poly-ubiquitinated protein degraded? The  26S proteasome  is  the  m a c hine ry tha t  s pe c ific a lly de g ra de s  po ly-ub iq uitina te d pro te ins . It is : a multi-subunit protease. very abundant (~1% of the cellular proteins). present in both the cytoplasm and the nucleus. dependent on ATP for activity.
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 26

Handout 4 - MCB252Cells&TissuesFall2009 Handout4 I. The...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online