Handout 6 - MCB 252 Cells & Tissues Fall 2008...

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Unformatted text preview: MCB 252 Cells & Tissues Fall 2008 Handout 6 I. The Cellular Per ipher y and I ts Role in Contr olling Gene Expr ession II. Tr anscr iptional Contr ol of Gene Expr ession a) The N uclear Per ipher y b) N ucleo-cytoplasmic Tr afficking I c) N ucleo-cytoplasmic Tr afficking I I a) Chromosome Organization and Gene Regulation I a) Chr omosome Or ganization and Gene Regulation I I I. Tr anslational Contr ol of Gene Expr ession MCB 252 Cells & Tissues Fall 2008 Handout 6 New questions: How is the expression of a gene regulated at the transcriptional level? How is the expression of a gene regulated at the post-transcriptional level? How are mRNAs exported to the cytoplasm? What regulates protein homeostasis? I I . Chromosome Organization and Gene Regulation I MCB 252 Cells & Tissues Fall 2008 Handout 6 I I . Chromosome Organization and Gene Regulation I Signal: Reception Amplification Transmission Response: Activation/ Repressio n of genes Distribution of the genetic information MCB 252 Cells & Tissues Fall 2008 Handout 6 Genes and the general transcription machinery. I I . Chromosome Organization and Gene Regulation I Regulation of transcription: I n eukaryotes, DNA is assembled into chromatin, which regulates access of the transcriptional machinery to genes. Regulation of transcription: A mammalian organism needs to regulate the expression of ~20,000-25,000 protein-coding genes Genes and the general transcription machinery. Transcription factors: activators and repressors. Genes and the general transcription machinery. Transcription factors: activators and repressors. Chromatin: organization and dynamics. MCB 252 Cells & Tissues Fall 2008 Handout 6 Gene: (before 1940s) A region of the genome that segregates as a single unit during meiosis and give rise to a definable phenotypic trait (red/ white eye in Drosophila)....
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This note was uploaded on 06/12/2010 for the course MCB 252 taught by Professor Prasanth during the Spring '08 term at University of Illinois at Urbana–Champaign.

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Handout 6 - MCB 252 Cells & Tissues Fall 2008...

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