Handout 8 - MCB252Cells& II. Euchromatin Heterochromatin...

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MCB 252 Cells & Tissues Fall 2009    Handout 8 II. Chromosome Organization and Gene Regulation II Euchromatin Heterochromatin
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MCB 252 Cells & Tissues Fall 2009    Handout 8 II. Chromosome Organization and Gene Regulation II During interphase chromosomes occupy distinct domains of the nucleus  referred to as “Chromosome territories”. Chromosomes are visualized by  f luorescent i n-s itu h ybridization  (FISH). The two chromosome 7s of a  human lymphocyte.
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MCB 252 Cells & Tissues Fall 2009    Handout 8 II. Chromosome Organization and Gene Regulation II
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MCB 252 Cells & Tissues Fall 2009    Handout 8 II. Chromosome Organization and Gene Regulation II
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MCB 252 Cells & Tissues Fall 2009    Handout 8 II. Chromosome Organization and Gene Regulation II This technique is called: Chromosome Painting
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MCB 252 Cells & Tissues Fall 2009    Handout 8 Figure 4-65 Molecular Biology of the Cell (© Garland Science 2008)
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MCB 252 Cells & Tissues Fall 2009    Handout 8 Figure 4-66 Molecular Biology of the Cell (© Garland Science 2008)
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MCB 252 Cells & Tissues Fall 2009    Handout 8 Chuang et al., 2006 Curr. Biology 16: 825-831 Long range movement of gene locus
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MCB 252 Cells & Tissues Fall 2009    Handout 8 II. Chromosome Organization and Gene Regulation II ? Closed State  Chromatin Open State  Chromatin Chromatin  Romodeling
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MCB 252 Cells & Tissues Fall 2009    Handout 8 How does  transcription regulated by gene regulatory proteins?
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MCB 252 Cells & Tissues Fall 2009    Handout 8 II. Chromosome Organization and Gene Regulation II Genetic links between gene activation and chromatin: 1. Nucleosome depletion in vivo was found to result in a general  activation of transcription. This result suggested that nucleosome 
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