Handout 10 part 1

Handout 10 part 1 -...

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Handout 10 New questions: How is the expression of a gene regulated at the transcriptional  level? How is the expression of a gene regulated at the post- transcriptional level? How are mRNAs exported to the cytoplasm? What regulates protein homeostasis?
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Handout 10 Cytoplasm Nucleoplasm Export Chromatin Gene pre-mRNA processing Transcription pre-mRNA Capping AAAAA Cleavage and Polyadenylation Me AAAAA Splicing mRNA Me • Post-transcriptional regulations
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Handout 10 Transcription elongation C hro m a tin PolII • Post-transcriptional regulations Ribonucleoprotein particle RNA binding proteins PolII Cap binding complex
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Handout 10 RNA pol II CTD phosphorylation is crucial for 5’ capping  
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Handout 10 Transcription elongation Chromatin • Post-transcriptional regulations PolII intronic sequence PolII splicing machinery (spliceosome)
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Handout 10 Transcription elongation • Post-transcriptional regulations Chromatin PolII AAAUAA G/U Poly A tail 3’ PolII
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Handout 10 Cytoplasm Nucleoplasm Export Chromatin Gene pre-mRNA processing Transcription pre-mRNA Capping AAAAA Cleavage and Polyadenylation Me AAAAA Splicing mRNA Me Post-transcriptional regulations
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Handout 10 pre-mRNAs are:  very heterogeneous in size, ranging from 1 to 100 Kb (In  contrast mRNAs are a more homogeneous with an average size of  2 Kb). Nuclear
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Handout 10 part 1 -...

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