Handout 10 part 2 - MCB252Cells& MCB252Cells& THE NUCLEUS...

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Handout 10 Gene regulation by differential cleavage and polyadenylation
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Handout 10 THE NUCLEUS Prasanth, K V And Spector, D L (2006) The Cell Nucleus: ENCYCLOPEDIA OF LIFE SCIENCES . Prasanth et al., 2003 Mol. Biol. Cell 3: 1043-57
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Handout 10 Sub-nuclear domains
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Handout 10 Cellular distribution of the splicing factors Splicing components are scattered throughout  the nucleus, but concentrated in domains called  speckles, or I nterchromatin G ranule C lusters  (IGCs).  At the electron microscopy level, IGCs  appear to be composed of 20-25nm particles  connected by thin fibrils. IGCs are not sites for  pre mRNA splicing. Rather, splicing  components are recruited from IGCs to  transcription sites. IGCs are dynamic structures.
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This note was uploaded on 06/12/2010 for the course MCB 252 taught by Professor Prasanth during the Spring '08 term at University of Illinois at Urbana–Champaign.

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Handout 10 part 2 - MCB252Cells& MCB252Cells& THE NUCLEUS...

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