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Unformatted text preview: molecule that binds to the NLS and takes it to the nucleus. Know Ras, Ran, MAP kinase. While we do not kneed to know the nucleoporins or which amino acid is being phosphorilated BUT make sure you know the specific protein s in the pathways we have discussed. What does the nuclear export signal in I-Kappa-B important? It is important because it is bound to NF-Kappa-B and this prevents the importin from binding to the NF-Kappa B. Once it gets degraded the NF-Kappa-B can and will go into the nucleus because it is a transcription factor. However, eventually it needs to be inhibited again and I-Kappa-B will move into the nucleus and bind to the NF-Kappa-B. Now, due to the NES the I-Kappa-B binded to the NF-Kappa-B can move back out to the cytoplasm....
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- Spring '08
- cell biology