take_home_key - Please answer on a blue scantron form Make...

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Please answer on a blue scantron form. Make sure that your name is on it and that your student ID and “FORM A ” has been filled in. If it’s not, it won’t be graded. This is open-book/open note, but must represent your own work. Consider this part of your final exam. The point of going to school is to learn stuff; if you cheat, you don’t learn— so, it’s morally reprehensible and inefficient. If you have been found to be cheating (either giving or taking answers), you’ll get a zero on this. All questions have one best answer. Genome sequencing is all the rage nowadays; there is an X-prize for whoever can deliver a human genome sequence for under $100, and this prize will probably be claimed within a decade. A lot can be learned from a genome, so people have been working hard on this problem for a long time—the first genome was sequenced in 1995, and a human genome was sequenced not too long after. We are now in the “post-genomic era,” so it is useful to think about biology in the light of DNA information. 1. A sequenced genome is nothing more than a string of nucleotide sequence unique to a particular organism. What describes what we can get out of this information? a) a complete understanding of everything in the organism b) testable hypotheses about what genes it has and what capabilities it might show c) knowledge about every protein and stable RNA the organism can make d) proof of the organism’s evolutionary history e) all of the above 2. The first organism to have its entire genome sequenced was the Bacterium Haemophilus influenzae . As a member of the Bacteria, it is characterized by which of these features? a) small, simple cells b) a cell wall c) a circular chromosome d) RNA polymerase that uses a sigma subunit to recognize a promoter e) all of the above 3. H. influenzae is a parasite on humans; inside our bodies, it has access to abundant reduced carbon, and generates energy by fermentation. Which of these processes is NOT part of fermentation in this organism? a) oxidation of organic compounds from Haemophilus’ environment b) production of organic acids and/or CO 2 and alcohols. c) ATP synthesis by chemiosmosis d) enzymatic coupling of carbon oxidation ( G << 0) and formation of high-energy compounds ( G > 0), with the net G < 0 e) all of the above occur during fermentation in Haemophilus 4. The genome of H. influenzae lacks ten of the genes required for synthesis of NAD+; it obtains this from its host (us). What is the role of NAD+ in the metabolism of H. influenzae ? a) it is an electron carrier b) it is an oxidoreductase c) it is has high-energy bonds that can be hydrolyzed, providing energy for ATP synthesis d) it is an enzyme e) it is a ribozyme 1
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5. Simply from looking at the DNA sequence of H. influenzae , researchers were able to conclude that it expressed the genes for glycolytic enzymes at a very high level. How? a) the genes were present in many copies per cell
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take_home_key - Please answer on a blue scantron form Make...

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