oldfinalkey - Mic102/Win08/Appleman Final, 19 March 2008...

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1 Mic102/Win08/Appleman Final, 19 March 2008 This exam is to represent only your own work . As a UC Davis student, you are bound by an honor code; if you can’t be trusted with that, can you be trusted in a career in, say, the health professions? This quiz is closed book, closed note. Please hand in a blue scantron with the answers to the multiple choice section of the quiz. Make sure that it has your name, student I.D.#, and “ Test form C ” filled in. You will also need to hand in the last two pages of this quiz, with your name on each. As we enter into the 21 st century, we are dealing with a lot of very serious problems brought on by the excesses of the 19 th and 20 th centuries. Advances in technology, agriculture, and medicine have created wealth and spurred a dramatic increase in population: there are now six and a half billion of us, and we all seem to want an iPod and a nice car and decent medical care. The downside of this is that we have been consuming natural resources at an astounding rate, and changing the chemistry of the atmosphere and the ocean. So now we have to pay the bill: we have to deal with new diseases, we need to find new sources of energy, and we need to clean up the messes that we have made. There is no one solution to all of these problems, but an understanding of microbiology may prove helpful in finding our way to a more balanced mode of life.
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2 As we expand into new territories and industrialize food production we cause disruptions in ecosystems. This can upset commensal relationships, changing them to pathogenic relationships. An example of this is the increasing frequency of outbreaks of E. coli O157:H7, which is related to beef production using feedlots and high-throughput slaughterhouses. 1. E. coli is a normal member of the mammalian intestinal flora. As such, it contributes to our health by a) digesting polysaccharides we can’t digest b) producing vitamins c) improving our immune system d) all of the above 2. Most of the genes that make E. coli O157:H7 a pathogen are clustered in pathogenicity islands. Pathogenicity islands are a) operons b) regulons c) regions of the genome acquired by horizontal gene transfer, often in prophages d) concentrations of virulence factors on the surface of the cell 3. Which of these are not virulence factors for E. coli O157:H7 and similar pathogens? a) ribosomes b) lipopolysaccharides c) Shiga toxin and other A:B toxins d) pili 4. Over 20% of the E. coli O157:H7 genome is different from that of “normal” E. coli MG1655. Why are they considered to be the same species? a) they are found in the same place b) they are both Gram-negative c) they have the same appearance d) their rRNA sequences are identical 5. The best technique for discriminating between E. coli MG1655 and O157:H7 would be a) Gram staining b) MLST c) Transmission Electron Microscopy d) Phylogenetic staining Until the mid-20 th century, any bacterial infection could be fatal; people routinely died
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This note was uploaded on 06/15/2010 for the course MIC MIC 102 taught by Professor Alexappleman during the Spring '08 term at UC Davis.

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oldfinalkey - Mic102/Win08/Appleman Final, 19 March 2008...

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