quiz3key - Mic102/Win08/Appleman Quiz 3, 5 March 2008 This...

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Mic102/Win08/Appleman Quiz 3, 5 March 2008 This quiz is to represent only your own work . As a UC Davis student, you are bound by an honor code; if you can’t be trusted with that, can you be trusted in a career in, say, the health professions? This quiz is closed book, closed note. Please hand in a blue scantron with the answers to the multiple choice section of the quiz. Make sure that it has your name, student I.D.#, and “ Test form A ” filled in. You will also need to hand in the last two pages of this quiz, with your name on each. Cholera is a nightmare of a disease: it can be lethal within hours of the onset of symptoms, and if therapy is not promptly administered, it is fatal in most cases. Cholera is caused by the bacterium Vibrio cholerae , which is a normal member of marine ecosystems. Environmental changes can favor pathogenic strains of V. cholerae , and poor sanitation and crowding can lead to devastating outbreaks of cholera in human populations. The environmental conditions that favor pathogenic V. cholerae are warmer oceans and blooms of marine plankton—both conditions that are aggravated by human activity. So, don’t be surprised if we see more outbreaks of this disease in the future. To date, sixteen different isolates of Vibrio cholerae have been sequenced. The first isolate to be sequenced was a pathogenic strain, “El Tor 169161”, in 2000.
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1. Vibrio cholerae has two chromosomes. The smaller one is hypothesized to have originally been a “megaplasmid” that over time evolved into a chromosome. What must have happened for a plasmid to become a chromosome? a) it must have gotten larger b) it must have acquired genes essential to V. cholerae ’s survival--definition c) it must have lost selfish genes d) all of the above 2. One of the genes in V. cholerae, rtxA , is 13,365 bases long. This is a) about average for a bacterial gene b) about 10 times longer than a normal bacterial gene c) unusually short d) none of the above 3. The rtxA gene is 13,365 bases long; however, the active form of the RtxA protein is 3,428 amino acids in length. How can this be? a) the gene has a type I intron b) rtxA encodes an intein c) RtxA is processed as part of its maturation d) all of the above are possible in a Bacterium 4. rtxA is part of an operon with rtxC . This means that a) rtxA and rtxC use the same promoter b) rtxA and rtxC use the same Shine-Dalgarno site c) rtxA and rtxC use the same stop codon d) all of the above 5. Why is it convenient for V. cholerae to have the rtxA and rtxC genes in an operon? a) their mRNA is produced in equal amounts b) much of their expression is coregulated c) they have related functions d) all of the above 6. The smaller chromosome has an addiction module, encoded by the genes higB and doc . Which of these is not an essential feature of an addiction module? a) one of the genes encodes a toxin
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This note was uploaded on 06/15/2010 for the course MIC MIC 102 taught by Professor Alexappleman during the Spring '08 term at UC Davis.

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quiz3key - Mic102/Win08/Appleman Quiz 3, 5 March 2008 This...

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