BIO 213-F09 - Lecture 3 - Genetics DNA Structure, Protein Synthesis

BIO 213-F09 - Lecture 3 - Genetics DNA Structure, Protein Synthesis

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Genetics I Genetics I
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Lecture Overview – DNA • Structure • Replication – Protein Synthesis • Types of RNA • Transcription • Translation – Mendelian Genetics
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Structure of Nucleotides in DNA • Each nucleotide consists of – Deoxyribose (5-carbon sugar) – Phosphate group – A nitrogen-containing base • Four bases – Adenine, Guanine, Thymine, Cytosine
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Nucleotide Bases phosphate group deoxyribose ADENINE (A) THYMINE (T) CYTOSINE (C) GUANINE (G)
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Rosalind Franklin’s Work • Was an expert in x-ray crystallography • Used this technique to examine DNA • Concluded that DNA was some sort of helix • Phosphate bonds were on the outside of the molecule Rosalind Franklin 1920-1958, ca. 1950
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Watson-Crick Model • DNA consists of two nucleotide strands – Molecule is a double helix • Strands run in opposite directions – antiparallel • Strands are held together by hydrogen bonds between bases
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Watson-Crick Model http://www.youtube.com/watch?v=qy8dk5iS1f0
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DNA Structure Helps Explain How it Duplicates • DNA is two nucleotide strands held together by hydrogen bonds • Hydrogen bonds between two strands are easily broken • Each single strand then serves as template for new strand
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DNA Replication new new old old • Each parent strand remains intact • Every DNA molecule is half “old” and half “new” http://www.youtube.com/watch?v=hfZ8o9D1tus &feature=related
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Each old strand serves as the template for complementary new strand “Semiconservative”
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This note was uploaded on 06/15/2010 for the course BIO 213 taught by Professor Lee during the Fall '08 term at Cal Poly.

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BIO 213-F09 - Lecture 3 - Genetics DNA Structure, Protein Synthesis

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