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BIO 213-F09 - Lecture 3 - Genetics DNA Structure, Protein Synthesis

BIO 213-F09 - Lecture 3 - Genetics DNA Structure, Protein Synthesis

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Genetics I Genetics I
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Lecture Overview – DNA • Structure • Replication – Protein Synthesis Types of RNA • Transcription • Translation – Mendelian Genetics
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Structure of Nucleotides in DNA Each nucleotide consists of – Deoxyribose (5-carbon sugar) – Phosphate group – A nitrogen-containing base Four bases – Adenine, Guanine, Thymine, Cytosine
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Nucleotide Bases phosphate group deoxyribose ADENINE (A) THYMINE (T) CYTOSINE (C) GUANINE (G)
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Rosalind Franklin’s Work Was an expert in x-ray crystallography Used this technique to examine DNA Concluded that DNA was some sort of helix Phosphate bonds were on the outside of the molecule Rosalind Franklin 1920-1958, ca. 1950
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Watson-Crick Model DNA consists of two nucleotide strands – Molecule is a double helix Strands run in opposite directions – antiparallel Strands are held together by hydrogen bonds between bases
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Watson-Crick Model http://www.youtube.com/watch?v=qy8dk5iS1f0
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DNA Structure Helps Explain How it Duplicates DNA is two nucleotide strands held together by hydrogen bonds Hydrogen bonds between two strands are easily broken Each single strand then serves as template for new strand
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DNA Replication new new old old Each parent strand remains intact Every DNA molecule is half “old” and half “new” http://www.youtube.com/watch?v=hfZ8o9D1tus &feature=related
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Each old strand serves as the template for complementary new strand “Semiconservative”
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