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BRAE 213-F09 - Class 02 - Biotechnology

BRAE 213-F09 - Class 02 - Biotechnology - ENGR BRAE 213-71...

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9/28/2009 1 ENGR / BRAE 213-71 – Bioengineering Fundamentals Sep 30 th , 2009 Biotechnology Class Outline Review Quiz Case study in muscular dystrophy • Genomics Pharmacological therapies Gene therapies Protein therapies Case Study- Duchenne Muscular Dystrophy (DMD) Dystrophin Gene Mutation(s) Fiber Death Inflammation Fiber Regeneration Muscle fiber Limited
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9/28/2009 2 Case Study- Duchenne Muscular Dystrophy (DMD) Life Expectancy – 15-25 years Activity What is the most common cause of death in DMD patients A. Respiratory failure B Cardiac failure B. C. Systemic Infection D. Limb paralysis E. Other Genomics How do we know patient has mutation? – Sequencing – PCR
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9/28/2009 3 Genomics- Background DNA makes up genome “expressed gene” Mutations (single nucleotide polymorphism) Different nucleotides in DNA/RNA can lead to different amino acids in protein Person 1 Person 2 Genomics Technology- PCR Polymerase Chain Reaction – amplify DNA
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9/28/2009 4 Genomics Technology- PCR http://highered.mcgraw-hill.com/olc/dl/120078/micro15.swf Produce specificity with primers – 1 primer set for normal DNA
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