Unformatted text preview: TRIAL EXAMINATION 3 SPRING SESSION 2008
COLLEGE OF HEALTH AND SCIENCE
Student Name: Student Number: Course: Unit Name: Unit Number: Time Allowed: Number of Questions: Total Number of Pages: Lecturer's Name: MEDICINAL CHEMISTRY 300550 Thirty minutes. (See note below) 10 (See note below) Trevor D. Bailey INSTRUCTIONS PLEASE READ CAREFULLY BEFORE PROCEEDING 1 2 3 4 5 Write your name and student number on the top of this examination paper and on each answer sheet that you use. This is a closed book examination. Answer all questions on the Answer Sheet provided. All questions are of equal value. Calculators are permissible (non-programmable only). DO NOT TAKE THIS PAPER FROM THE EXAMINATION ROOM Note: The actual Final Examination is 3 hours duration, plus ten minutes reading time, with 60 questions. These questions are similar in layout and complexity to the Final Examination. Medicinal Chemistry Trial Questions Page 1 of 5 *** ANSWER ALL QUESTIONS *** 1. For the following diagram showing a potential energy plot for a chemical reaction:
A Potential energy E2 E1
H C B Reaction coordinate Which of the following statements is wrong? (a) H is (+) (b) Adding a catalyst has no effect on H (c) Adding a catalyst lowers E1 (d) E2 is the activation energy (e) Adding a catalyst lowers the potential energy of B 2. For the coordination complex [Cr(en)2Cl2], the coordination number is: (a) 0 (b) 2 (c) 3 (d) 4 (e) 6 3. For the coordination complex [NiCl4]2-, the oxidation state of the metal is: (a) 2+ (b) 2(c) 1+ (d) 1(e) 4+ 4. The best reagent to convert 1-pentanol to 1-bromopentane would be (a) HBr (b) NaBr (c) PBr3 (d) bromobenzene Medicinal Chemistry Trial Questions Page 2 of 5 5. The reaction of 1-bromohexane with sodium ethoxide in ethanol at 80o affords ethyl hexyl ether and 1-hexene. To form 1-hexene ONLY we would use: (a) hexyl methyl ether and sodium hydroxide in water (b) 1-bromohexxane and sodium hydroxide in water at room temperature (c) 1-chlorohexane and sodium ethoxide (NaOEt) in ethanol at 80o (d) 1-bromohexane and potassium tert-butoxide (sterically hindered base) in tertbutanol 6. In a bimolecular nucleophilic substitution reaction there is/ are (a) 2 steps (b) no intermediates (c) one chemical species only in the rate determining step (d) no transition state. 7. Which of the following compounds is/are chiral? (a) 1 and 3 (b) 1 and 2 (c) 2 only (d) 2 and 4 (e) 1, 2 and 4
1 HO HO CH2COOH H H CH2COOH 2 HO HO CH3 H H CH2COOH 3 4 NH2 COOH OH 8. Which of the following is not a primary amine? (a) 1-Butylamine (b) Cyclohexylamine (c) 3-Hexylamine (d) Diethylamine Medicinal Chemistry Trial Questions Page 3 of 5 9. What is the major product of the following reaction?
O O + CH3CH2NH2 O O (a) N (b) N O O (c) O H N HO O (d) N H O O O H N Medicinal Chemistry Trial Questions Page 4 of 5 10. Which of the following represents the amino acid alanine at a pH = 12?
+H N 3 CH3 C H COOH (b)
+H N 3 CH3 C H COO- (c) CH3 H2N C H COOH (d) CH3 H2N C H COO- (e) CH2CH3
+H N 3 C H COO- Medicinal Chemistry Trial Questions Page 5 of 5 ...
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