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Unit1-1STUDENTS - Bio 1 0 7 A Instructor Dr Sonia Zarate De...

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Bio  107A Instructor: Dr. Sonia Zarate                                                 De pt. o f B & PS BATC H 3217 951-827-7056 s o nia.zarate @ uc r.e du         Office   Hours: LS P 2400 Mo nday  9-10 We dne s day  9-10 o r by Appo intm e nt Teaching Assistants: Linda Robles-Morales Dept. of Biochemistry BOYCE 3470 [email protected] Office Hours: Boyce 4473 Wednesday 9-10 Thursday  9-10 or by appointment Linh Vuong Dept. of Cell Bio/Neuro Sci  BIO SCI 2226 951-827-3246 [email protected] Office Hours: LSP 2615 Friday 2-3PM or by appointment 
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Materials: Textbook:    MO LEC ULAR BIO LO G Y    (4 th  Edition) by R.F. Weaver    a copy have been placed on reserve in the Science  Library Other required materials:   Pe rs o nal re s po ns e  s ys te m  (PRS /c lic ke rs )   Purc has e  at the  bo o ks to re  and re g is te r by  4/7/09 at:     http://c lic ke rs .uc r.e du
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Grading: PRS/Clicker questions 5% Quizzes 10 % Discussion 5 % Assignments 5 % Midterm 1 20 % Midterm 2 20 % Final exam 35 %
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Grading Grading is on a traditional scale: A 90-100 B 80-89 C 70-79 D 60-69 F <59
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Class web site: http://ilearn.ucr.edu   Abbre viate d le c ture  no te s  fo r e ac h unit will be   po s te d o n the  we b s ite .  Pro ble m  s e ts  will be  po s te d e ac h we e k. o ne   we e k late r, the  ans we rs  will be  po s te d (afte r the   pro ble m  s e ts  are  hande d in) . Ke ys  to  q uizze s  and e xam s  will be  po s te d**
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PRS/Clickers To tal 50 q ue s tio ns  (e xam ple ): C o rre c t Ans we r 3 po ints Inc o rre c t Ans we r 1 po int Minim um  to  g e t 5%  is  50 po ints Jus t ans we ring  e ve ry q ue s tio n will e arn  yo u 50 po ints !
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WHAT IS MOLECULAR BIOLOGY? 1. Study of nucleic acids and their activities at the molecular level Transcription Translation recombination DNA replication 2. Using our understanding to manipulate genes and genomes, i.e. genetic engineering
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DNA RNA Protein Protein synthesis (translation) RNA synthesis (transcription) DNA replication CENTRAL DOGMA
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Unit 1: Nucleic Acid Structure Reading: Weaver pp. 13 - 30
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Identification of Nucleic Acids (DNA and RNA) as the Genetic Material Part I
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Mendel showed that inheritance was particulate, not blended (1863) Genes exist in different forms (alleles) Background What is the chemical nature of genes?
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Chromosomes are units of inheritance (early 1900s)
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What is the chemical nature of the genetic material?
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Chromosomes are in nucleus (in eukaryotes) Chromosomes carry genes Genes must be in nucleus What kinds of chemicals are in the nucleus?
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Miescher asked what chemicals were in the nucleus (1869) Isolated nuclei from white blood cells (large nuclei) from pus in surgical bandages
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Chemical analyses showed that nuclei are rich in phosphorus, oxygen, nitrogen, carbon, and hydrogen Miescher called the substance nuclein He was actually looking at a mixture of DNA and protein
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