Unit1-1STUDENTS - Bio 1 0 7 A Instructor: Dr. Sonia Zarate...

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Bio  107A Instructor: Dr. Sonia Zarate                                                 BATC H 3217 951-827-7056 s o nia .za ra te @ uc r.e du         Office   Hours: LS P 2400 Mo nda y  9-10 We dne s da y  9-10 o r b y Appo intm e nt Teaching Assistants: Linda Robles-Morales Dept. of Biochemistry BOYCE 3470 morall02@student.ucr.edu Office Hours: Boyce 4473 Wednesday 9-10 Thursday  9-10 or by appointment Linh Vuong Dept. of Cell Bio/Neuro Sci  BIO SCI 2226 951-827-3246 lvuon002@student.ucr.edu Office Hours: LSP 2615 Friday 2-3PM or by appointment 
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Materials: Textbook:    MO LEC ULAR BIO LO G Y    (4 th  Edition) by R.F. Weaver    a copy have been placed on reserve in the Science  Library Other required materials:   Pe rs o na l re s po ns e  s ys te m  (PRS /c lic ke rs )   Purc ha s e  a t the  b o o ks to re  a nd re g is te r b y  4/7/09 a t:     http://c lic ke rs .uc r.e du
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Grading: PRS/Clicker questions 5% Quizzes 10 % Discussion 5 % Assignments 5 % Midterm 1 20 % Midterm 2 20 % Final exam 35 %
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Grading Grading is on a traditional scale: A 90-100 B 80-89 C 70-79 D 60-69 F <59
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Class web site: http://ilearn.ucr.edu   Ab b re via te d le c ture  no te s  fo r e a c h unit will b e   po s te d o n the  we b  s ite .  Pro b le m  s e ts  will b e  po s te d e a c h we e k. o ne   we e k la te r, the  a ns we rs  will b e  po s te d (a fte r the   pro b le m  s e ts  a re  ha nde d in) . Ke ys  to  q uizze s  a nd e xa m s  will b e  po s te d**
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PRS/Clickers To ta l 50 q ue s tio ns  (e xa m ple ): C o rre c t Ans we r 3 po ints Inc o rre c t Ans we r 1 po int Minim um  to  g e t 5%  is  50 po ints Jus t a ns we ring  e ve ry q ue s tio n will e a rn  yo u 50 po ints !
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WHAT IS MOLECULAR BIOLOGY? 1. Study of nucleic acids and their activities at the molecular level Transcription Translation recombination DNA replication 2. Using our understanding to manipulate genes and genomes, i.e. genetic engineering
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DNA RNA Protein Protein synthesis (translation) RNA synthesis (transcription) DNA replication CENTRAL DOGMA
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Unit 1: Nucleic Acid Structure Reading: Weaver pp. 13 - 30
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Identification of Nucleic Acids (DNA and RNA) as the Genetic Material Part I
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Mendel showed that inheritance was particulate, not blended (1863) Genes exist in different forms (alleles) Background What is the chemical nature of genes?
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Chromosomes are units of inheritance (early 1900s)
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What is the chemical nature of the genetic material?
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Chromosomes are in nucleus (in eukaryotes) Chromosomes carry genes Genes must be in nucleus What kinds of chemicals are in the nucleus?
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Miescher asked what chemicals were in the nucleus (1869) Isolated nuclei from white blood cells (large nuclei) from pus in surgical bandages
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Chemical analyses showed that
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Unit1-1STUDENTS - Bio 1 0 7 A Instructor: Dr. Sonia Zarate...

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