ImmunityII

ImmunityII - The Generation of Specific Immunity Antibody...

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The Generation of Specific Immunity
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Antibody structure ! Antibodies classified by specificity (antigen, binding site) and class (general structure, function) ! Differences in variable regions produce different specificities; differences in constant regions produce different classes of antibodies ! Survey of effective antigens suggests that thousands of antibodies are possible
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Antibody formation Multiple exposures to antigen induce a “memory response” (blue) (red) IgM IgG IgM
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Questions ... ! Why is there a memory response? ! With so many antibodies, why are there none that react with one’s own proteins? ! Where do all the specific binding sites come from? ! How is the genetic information for that many proteins stored? ! How and why does the type of immunoglobulin change after reinnoculation? ! How are antibodies induced by the presence of antigen?
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There are several types of lymphocytes involved in the immune response (B for bone) (T for thymus)
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Clonal selection Why is there a memory response? ! Lymphocyte stem cells (B cells and others)
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This note was uploaded on 06/18/2010 for the course BIS 103 taught by Professor Abel during the Spring '08 term at UC Davis.

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ImmunityII - The Generation of Specific Immunity Antibody...

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