Mutagenesis

Mutagenesis - MUTATIONS MUTAGENESIS AND CARCINOGENESIS How...

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MUTATIONS, MUTAGENESIS, AND CARCINOGENESIS
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How do different alleles arise? (“allele”: form of a gene; specific base sequence at a site on DNA) Mutations: heritable changes in genes Mutations occur in DNA But their effects involve proteins Structural genes Silent Mis-sense Nonsense Frameshift Intron/exon boundaries (splicing) Control genes Promoter/enhancer sequences Transcription factors Point mutations
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Which would have the most severe effect on a gene product’s (protein’s) structure? (a) Changing a base in the gene, e.g. a C to a G. (b) Changing an AUG codon to a UAG. (c) Adding a base after the first codon of the gene. (d) Adding two bases after the first codon of the gene. (e) Adding three bases after the first codon of the gene.
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A base change that leads to a new codon for the same amino acid is a silent mutation.
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acid is a mis-sense mutation. Original sequence:
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This note was uploaded on 06/18/2010 for the course BIS 103 taught by Professor Abel during the Spring '08 term at UC Davis.

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Mutagenesis - MUTATIONS MUTAGENESIS AND CARCINOGENESIS How...

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