ON- and OFF-bipolar cells

ON- and OFF-bipolar cells - r opposite is true for ON...

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Sheet1 Page 1 ON-and OFF-bipolar cells h The photoreceptors make synaptic connections onto ON and OFF bipolar cells. The ON and OFF bipolar cellshave different responses to the glutamate released fromthe photorecepto h OFF bipolar cells depolarize in response to glutamate, while ON bipolar cells hyperpolarize in response toglutamate. h Because light hyperpolarizes photoreceptors, and they release less glutamate when they are hyperpolarized, an OFF bipolar cell will hyperpolarize when light shines on the photoreceptor it is connected to (less glutamatebeing released), and depolarize when there is no light onthe photorecepto
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Unformatted text preview: r opposite is true for ON bipolar cells. o ON-and OFF-bipolar cells h Photoreceptor releases glutamate when depolarized h OFF-bipolar cells have ionotropic glutamate receptors (AMPA + kainate). Glutamate depolarizes them. h ON-bipolar cells have G-protein coupled metabotropic receptors (mGLUR6). Glutamate hyperpolarizes them. glutamate mGluR6 AMPA kainate glutamate AMPA kainate NMDA N A dark spot in the center has the opposite effect e...
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