NPB.101.09.BasicCncpts - NPB 101 Autumn 2009. Basic...

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NPB 101 Autumn 2009. Basic Principles Throughout this course there have been recurring themes and concepts that underlie physiology in general. Understanding these basic concepts will greatly improve learning and comprehension of modern physiology. Below is an outline of which basic processes should be studied in depth. Cell-cell interrelationships, adhesion, gap junctions, tight junctions, blood tissue barriers. Transport mechanisms, passive diffusion, facilitated diffusion, active transport, carrier proteins across cell membranes. Protein synthesis, modification of proteins by glycosylation, phosphorylation etc. Packaging into secretory granules, constitutive and regulated secretion. Synthesis of non-protein neurotransmitters, neuromodulators and hormones (e.g. catecholamines, eicanosoids, steroids). Some of the latter are stored in secretory granules (e.g. catecholamines) some are not (e.g. steroids). Secretion by exocytosis, the opposite is endocytosis. Receptor mediated endocytosis. Autocrine, paracrine and endocrine secretions. Membrane potentials, graded and action potentials. Synaptic transmission, presynaptic and postsynaptic neuromodulation. Transport of chemical messengers (e.g. neurophysins, binding proteins in blood). Properties of carrier proteins in general, as well as cell receptors membrane and internal). These properties are high affinity (strong binding but reversible), low capacity (few binding sites per receptor molecule), and high specificity (usually binds only one messenger and no others). Types of chemical messenger receptor. Membrane: G proteins (inhibitory and stimulatory), tyrosine kinase types, receptor on ion channels, early and late cell responses. Intracellular types 1, 2 and 3. Gene transcription factors, DNA-binding domain. Co-activators, co-suppressors.
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This note was uploaded on 06/23/2010 for the course NPB 101 taught by Professor Fuller,charles/goldberg,jack during the Fall '08 term at UC Davis.

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NPB.101.09.BasicCncpts - NPB 101 Autumn 2009. Basic...

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