BIS 152 Homework 4

BIS 152 Homework 4 - Shivali Gupta October 6, 2009 B IS 152...

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Shivali Gupta October 6, 2009 BIS 152 Section 001 Maria Pallavicini T.A. Heather Bryan Homework 4 Chapter 7: #1, 3, and 5 Chapter 8: #2, and 3 1. Why is the inheritance of mutant, activated oncogenes responsible for only a small proportion of familial cancer syndromes, while the inheritance of defective tumor suppressor genes (TSGs) is responsible for the lion’s share of these diseases? The inheritance of mutant activated oncogenes are responsible for only a small proportion of familial cancer syndromes, compared to the inheritance of defective tumor suppressor genes (TSGs) is responsible for the lion’s share of these diseases, because the inheritance of defective tumor suppressor genes increases the chance of loss of the other gene. Therefore the loss of both TSG genes results in an increase of the likelihood that the cell will undergo neoplastic transformation. 3. How might the loss of the TSG function yield an outcome that is, at the cell biological level, indistinguishable from the acquisition of an active oncogene? The loss of the TSG function
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BIS 152 Homework 4 - Shivali Gupta October 6, 2009 B IS 152...

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