BIS 152 Homework 5

BIS 152 Homework 5 - Shivali Gupta October 13, 2009 BIS 152...

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Shivali Gupta October 13, 2009 BIS 152 Section 001 Maria Pallavicini T.A. Heather Bryan Homework 5 Chapter 8: # 6 and 8 Chapter 9: # 1, 3, and 6 6. How do cells ensure that the transcription-activating functions of E2F transcription factors are limited to a narrow window of time in the cell cycle? What might occur if E2F function were allowed to continue throughout the cell cycle? Cells ensure that the transcription-activating functions of E2F transcription factors are limited to a narrow window of time in the cell cycle by allowing pRb to undergo phosphorylation through certain advancements through the cell cycle. The phosphorylation of pRb suppresses the function of pRb which is to suppress the activation of the E2F transcription factors. Usually pRb is unphosphorylated when cells are in G 0 ; which becomes weakly hypophosphorylated on a small number of serine and threonine residues after cells enter into the G 1 phase and then becomes extensively phosphorylated on a lot more serine and threonine residues as advancement through the R point. Once cells have passed the R point, pRb usually
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This note was uploaded on 06/23/2010 for the course BIO Bioap taught by Professor Ling during the Spring '10 term at UCM.

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BIS 152 Homework 5 - Shivali Gupta October 13, 2009 BIS 152...

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