BIS 152 Homework 6

BIS 152 Homework 6 - Shivali Gupta October 20, 2009 B IS...

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Shivali Gupta October 20, 2009 BIS 152 Section 001 Maria Pallavicini T.A. Heather Bryan Homework 6 Chapter 10: # 1, 2, 4, 5, and 6 1. What advantages do breakage-fusion-bridge cycles confer on evolving populations of pre- malignant cells? One advantage that the breakage-fusion-bridge cycles confer on evolving populations of pre- malignant cells is that they allow for abnormal chromosomes to form which can lead to underexpression or overexpression of genes located on the chromosomes due to chromosomal abnormalities such as nonreciprocal translocation, gene deletion, and gene amplification. Breakage-fusion-bridge cycles lead to telomere shortening which cause cells to undergo the state of crisis which allows for chromosomes to fuse to nonhomologous chromosomes resulting as abnormalities in the karyotype. 2. Why is the acquisition of an immortalized proliferative potential so important for human tumors? The acquisition of an immortalized proliferative potential is really important for human
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This note was uploaded on 06/23/2010 for the course BIO Bioap taught by Professor Ling during the Spring '10 term at UCM.

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BIS 152 Homework 6 - Shivali Gupta October 20, 2009 B IS...

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