BIS 152 Homework 9

BIS 152 Homework 9 - Shivali Gupta November 17, 2009 B IS...

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Shivali Gupta November 17, 2009 BIS 152 Section 001 Maria Pallavicini T.A. Heather Bryan Homework 9 Chapter 14: # 1, 2, 5, 7 and 8 What arguments can be mustered for or against the notion that invasion and metastasis are likely to be orchestrated by specific mutant alleles that are acquired by cancer cells late in tumor progression? In order for tumor cells to metastasize to new locations in the body of an organism, they must obtain the ability to move. Tumor cells achieve motility by the EMT, in which the epithelial cells undergo a transition to mesenchymal cells. In this process the epithelial cells shed their characteristic morphology and gene expression pattern and carry on the shape and transcriptional program characteristic of the mesenchymal cells. In this process the epithelial cells also lose the expression of the E-cadherin that binds them to other epithelial cells in the surrounding tissue, thus N-cadherin replaces E-cadherin which is much weaker than E-cadherin. The expression of the gene expressing the E-cadherin molecules can be
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BIS 152 Homework 9 - Shivali Gupta November 17, 2009 B IS...

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