suppl1 for study guide MT2 Part1

suppl1 for study guide MT2 Part1 - SUPPLEMENT-1 for Study...

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SUPPLEMENT-1 for Study guide for Midterm 2 BIS103-002 SQ2010 RE#3 in Part 1: >Hey, I got confused again!! Isn’t the question #3 inconsistent with what Dr. Inoue was talking about? I remember that he said that we should remember structures of ONLY three TCA cycle intermediates, citrate, α -ketoglutarate, and oxaloacetate, but NOT ALL of them!! >>Hmm. . I also remember that he was saying that if we know the structures of those three intermediates and if we know how TCA cycle works, we should be able to come up with the structures of other five intermediates. >HOW THE HECK CAN WE DO THAT?? >>Let me try. . well, I am looking at the structures of citrate and α -ketoglutarate. Oh, I found that citrate has six carbons but α -ketoglutarate has only five. And also the position of oxygen is different. This means that citrate has to be changed to something and gets decarboxylated. And the carboxyl group in the middle should be the one that has to be gone. Decarboxylation… sounds familiar…
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suppl1 for study guide MT2 Part1 - SUPPLEMENT-1 for Study...

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