BIS 104 Mukouyama definitions spr 2010

BIS 104 Mukouyama definitions spr 2010 - 6 Cell...

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Mukouyama, et al. Cell, 2002 Definitions 1. Peripheral sensory nerves Peripheral sensory nerves (PSNs) consist of two cell types: neurons and Schwann cells. The neurons are the electrically excitable cells; Schwann cells provide support and insulation for the neurons. 2. Endothelial cells Endothelial cells (ECs) are the cells that line the inner lumen of all parts of the vasculature: veins, arteries, heart. During embryonic development ECs are the first cells to organize into tubular capillaries that later differentiate into either veins or arteries. 3. Vasculogenesis The initial formation (genesis) and patterning of blood vessels during embryonic development. 4. Angiogenesis Refers to the normal remodeling of pre-existing blood vessels. It also occurs during wound healing, tissue repair, and tumor growth. 5. Cell differentiation (cytodifferentiation) Refers to the expression of cell-specific genes that lead to a specialized (differentiated) cell phenotype. A differentiated cell has a unique biochemistry, morphology, and function.
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Unformatted text preview: 6. Cell differentiation “markers” These “markers’ refer to gene products (usually proteins) that are characteristic and unique to a specific cell type. (e.g., the ephrinB2 transmembrane protein found only in differentiated arterial ECs). EphrinB2 is not expressed in undifferentiated ECs or in venous endothelial cells. 7. Immunocyto (histo) chemistry A technique used to identify and locate cell-specific markers on cells or tissues by using a labeled antibody and a microscopic technique to visualize the label. 8. Scanning confocal fluorescence microscopy A microscopic technique used to visualize fluorescently labeled antibodies or other fluorescent molecules bound to cells or tissues. 9. “E” “E” refers to the age of embryos. For example, E15.5 refers to a mouse embryo that is 15.5 days old (has developed in utero for 15.5 days since conception). Mice have a gestation period of 21 – 22 days....
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