BIS 102 Lecture 1

BIS 102 Lecture 1 - metabolites (pyruvate, succinate (OOCCH...

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6.22.10 Lecture 1 Quizzes every Thursday (12% each) Final on last Thursday (40%) Garrett/Grisham Biochemistry – Read chapters 1-2 P29-30 3,4 P49-50 1,2,3, 4,5,11 - Read ch 3 P74 1,2,3, Segel – P197-202 1,2,5,8 (Blue book) Sample proteins: MC1R Cytchromep450 DNA Polymerase I + III VEGF RNA polymerase Telomerase What we will study: Biomolecules: (carbon containing compounds, formed with covalent bonds) 1. Proteins (polymers of amino acids) 2. Polysaccharides (polymers of sugar glucose like monomer units) 3. Lipids (covalently linked fatty acids with glycerol) Proteins are comprised of amino acids. CO 2 , H 2 0, NH 3 , NO 3 - (inorganic reagents)
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Unformatted text preview: metabolites (pyruvate, succinate (OOCCH 2 CH 2 COO) nucleotides, sugars macromolecules organelles (mitochondria, nucleus, ER, Golgi) cell 1. pH = pKa + log (C b /C a ) 2. V o = [ V max [S] / K m + [S] ] 3. Delta G = Delta H T (Delta S) Delta G 0 = - RT ln (K eq ) Hydrogen covalent bond: 436 kJ Room temperature (RT) covalent bond: 2.5 kJ/mole Weak Forces:-Vander Waals forces (0.4kJ - 4kJ/mole)-Ionic interactions / Dipole-dipole interactions (20kJ/mole) -- distant dependent F= Q Dr 2-Hydrogen bonds (12kJ 30 kJ/ mole)-Hydrophobic interactions...
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BIS 102 Lecture 1 - metabolites (pyruvate, succinate (OOCCH...

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