Lecture 9 Aldol 040110

Lecture 9 Aldol 040110 - Lecture#9SolventFreeSynthesis...

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Lecture #9 – Solvent-Free Synthesis  of Chalcones 
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Clarification cis versus trans syn versus anti
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Chalcones Aldol Reaction Acetophenone  and  Benzaldehyde General : 1,3-Diphenyl-2-propen-1-one Alcohol + base required Natural products in plants Fertility of plant species Disease resistance Flower color regulation
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Who is interested in Chalcones? Pharmaceutical Companies Asthma, anti-inflammatory agents Anti-Cancer Agents Anti-fungal Anti-malaria therapies Insulin-like activity Industrial Applications Acetone + Benzaldehyde = Photoinitiator Academic labs Intermediates in chiral synthesis
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Chalcones are so cool, even Dr. Fry is  interested in them!   Hicks, L. D.; Fry, A. J.; Kurzweil, V. C.  " Ab Initio  Computation of Electron Affinities of Substituted  Benzalacetophenones (Chalcones). A New Approach to  Substituent Effects in Organic Electrochemistry“ Electrochimica Acta,  2004 ,  50,  1039
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Green Synthesis No solvent – our reaction Usually in alcoholic or protic solvent
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Lecture 9 Aldol 040110 - Lecture#9SolventFreeSynthesis...

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