09_18_09_MOL215

09_18_09_MOL215 - 4 Thus DNA replication must be continuous...

Info iconThis preview shows pages 1–17. Sign up to view the full content.

View Full Document Right Arrow Icon
Rosalind Franklin (1920-1958) ‘Photo 51’ www.pbs.org/wgbh/nova/photo51/
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
06_03_own duplication.jpg DNA replication is semi-conservative
Background image of page 2
06_04_replic.rounds.jpg
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Meselson & Stahl, PNAS 48 :671, 1957.
Background image of page 4
06_11_oppositepolarity.jpg
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
06_10_5prime_3prime.jpg
Background image of page 6
06_05_replic.origin.jpg
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
06_12_asymmetrical.jpg
Background image of page 8
06_09_Replic.forks.jpg
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 10
06_20_cancer_age.jpg Colon cancer incidence, England and Wales
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 12
06_13_polymerase1.jpg
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 16
Central ideas: 1. Complementarity suggests how DNA might replicate 2. Replication is semiconservative 3. DNA polymerase adds nucleotides to the 3’ OH only
Background image of page 17
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 4. Thus DNA replication must be continuous on one strand, discontinuous on the other 5. On the discontinuous strand, primers must be used 6. DNA ends must also be replicated 7. Genomes are therefore often circular and/or have telomeres 8. The addition of each base has an inescapable error probability 9. Proofreading is therefore necessar y Reading: Watson and Crick, Nature 1953 ECB3 Chpt 5, pp 171-178; Chpt 6, pp 197-216...
View Full Document

{[ snackBarMessage ]}

Page1 / 17

09_18_09_MOL215 - 4 Thus DNA replication must be continuous...

This preview shows document pages 1 - 17. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online