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gene key 4 - GENE 3200 Fall 2009 Bedell MWF Exam 4 Dec 7 ID...

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GENE 3200 – Fall 2009 – Bedell MWF - Exam 4 – Dec 7 ID no. 810__________ KEY ________________ 1 Write your ID number (810 number, NOT SSN) on every page. Write your initials on the first page only. All of the multiple choice questions have only one correct answer. The exam should be completed in ink. Regrades will not be given if you write in pencil. All requests to re-grade an exam must be made in writing to Dr. Bedell within 48 hours of the grades being posted on WebCT. 1. (1 pt) True or false. Genes for transfer RNAs (tRNAs) are transcribed by RNA polymerase III. 2. (1 pt) True or false. During gene expression in eukaryotes, enhancer elements determine that maximal transcription of a gene will occur. 3. (3 pts) In certain kinds of transcription factors, what is the main function of a leucine zipper? (a) It mediates the physical association of two polypeptides. (b) It anchors transcriptional activator proteins to enhancer sequences. (c) It releases leucines from misfolded transcription factors. (d) It integrates leucines and isoleucines into newly translated transcriptional activators. 4. (3 pts) Which of the following is NOT a mechanism employed by repressor proteins to decrease transcription of a specific gene? 5. (3 pts) In yeast of the α (alpha) mating type, what is the function of the α 2 gene product? 6. (3 pts) Which of the following is a cis-acting DNA sequence that functions to regulate a cluster of two or more related genes. 7. (1 pt) True or False . The main function of SWI/SNF proteins is to acetylate histones. 8. (1 pt) True or False. The presence of a DNase hypersensitive site suggests that chromatin is in an open state and available for transcription. 9. (3 pts) Which of the following is NOT true of epigenetic effects on gene expression? (a) DNA and/or histones associated with silenced genes are often highly methylated. (b) Gene silencing is associated with chromatin modification. (c) Gene silencing is associated with alterations in nucleotide sequence of enhancers. (d) All of the above are true.
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GENE 3200 – Fall 2009 – Bedell MWF - Exam 4 – Dec 7 ID no. 810__________ KEY ________________ 2 10. The pedigree to the right shows a disease that is associated with the inheritance of a rare mutant allele of an imprinted autosomal gene. Individual I-1 is known to be heterozygous for the mutant
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